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XCT 790

XCT 790 Structure
XCT 790
  • CAS No.725247-18-7
  • Chemical Name:XCT 790
  • CBNumber:CB7505302
  • Molecular Formula:C23H13F9N4O3S
  • Formula Weight:596.42
  • MOL File:725247-18-7.mol
XCT 790 Property
  • storage temp. 2-8°C
  • solubility DMSO: ≥10mg/mL
  • form solid
  • color yellow
  • FDA UNII A4CE428LGJ
  • UNSPSC Code 12352202
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H413
  • Precautionary statements P264-P270-P273-P301+P312-P330
XCT 790 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: X4753
  • Product name : XCT790
  • Purity: ≥98% (HPLC), solid
  • Packaging: 5MG
  • Price: ₹20643.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: X4753
  • Product name : XCT790
  • Purity: ≥98% (HPLC), solid
  • Packaging: 25MG
  • Price: ₹78946.73
  • Updated: 2022/06/14
  • Buy: Buy

XCT 790 Chemical Properties,Usage,Production

  • Description XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .
  • Uses XCT790 is a potent inverse agonist of ERRα.
  • Definition ChEBI: XCT 790 is a member of cinnamamides.
  • Biochem/physiol Actions XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).
  • storage Store at +4°C
  • References [1] lu x, peng l, lv m, ding k. recent advance in the design of small molecular modulators of estrogen-related receptors. curr pharm des. 2012;18(23):3421-31.
    [2] wu f, wang j, wang y, kwok tt, kong sk, wong c. estrogen-related receptor alpha (erralpha) inverse agonist xct-790 induces cell death in chemotherapeutic resistant cancer cells. chem biol interact. 2009 oct 7;181(2):236-42.
XCT 790 Preparation Products And Raw materials
Raw materials
Preparation Products
XCT 790 Suppliers
Global(83)Suppliers
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XCT 790 Spectrum
725247-18-7, XCT 790Related Search:
  • 抑制剂
  • 合成有机化合物配体
  • C23H13F9N4O3S
  • 化合物XCT790,10 MM DMSO 溶液
  • XCT 790,ERRΑ反向激动剂
  • 3-(4-((2,4-双(三氟甲基)苄基)氧基)-3-甲氧基苯基)-2-氰基-N-(5-(三氟甲基)-1,3,4-噻二唑-2-基)丙烯酰胺
  • XCT790类白色粉末
  • 化合物XCT790
  • 3-[4-[[2,4-二(三氟甲基)苄基]氧基]-3-甲氧基苯基]-2-氰基-N-(5-三氟甲基-[1,3,4]噻二唑-2-基)丙烯酰胺
  • 725247-18-7
  • XCT790, 10 mM in DMSO
  • XCT 790,Inhibitor,Estrogen Receptor/ERR,Autophagy,XCT790,inhibit,XCT-790
  • 2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-
  • CS-1881
  • XCT 790; XCT-790
  • (E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
  • XCT 790 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide
  • 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide XCT 790
  • 3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide

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