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4-(pyridine-2-yl) pyrimidin-2-amine

4-(pyridine-2-yl) pyrimidin-2-amine Structure
4-(pyridine-2-yl) pyrimidin-2-amine
  • CAS No.66521-65-1
  • Chemical Name:4-(pyridine-2-yl) pyrimidin-2-amine
  • CBNumber:CB7364224
  • Molecular Formula:C9H8N4
  • Formula Weight:172.19
  • MOL File:66521-65-1.mol
4-(pyridine-2-yl) pyrimidin-2-amine Property
  • Melting point 137-139°C
  • Boiling point 426.5±37.0 °C(Predicted)
  • Density 1.259±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • pka 3.34±0.10(Predicted)
  • form Solid
  • color Off-White to Pale Yellow
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • HazardClass  :IRRITANT
  • HS Code  :2933599590
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

4-(pyridine-2-yl) pyrimidin-2-amine Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Uses Intermediate in the preparation of Nilotinib.
  • Preparation Synthesis of 4-(pyridine-2-yl) pyrimidin-2-amine (P2P). (0.5 g, 2.84 mmol) of (Z)-3- dimethylamino-1-(pyridine-2-yl)prop-2-en-1-one was suspended was suspended in 15ml of nbutanol. To the solution (0.346 g, 2.84 mmol) of guanidine nitrate added and followed by the addition of NaOH(0.114 g, 2.84 mmol) and reflux this mixture at 110℃ for 12h. After completion of the reaction the mixture was filtered, the clear yellow solution of filtrate kept for room temperature. After 20 min yellow crystal formed and dried in a vacuum under reduced pressure. Yield (0.296 g, 60%) IR (KBr): 3471, 3142, 1622, 1568, 1463, 1340, 1215, 1095, 993, 783, 650, 524.1H NMR (300 MHz, CDCl3) δ 8.69 (dd, J = 11.9, 10.0 Hz, 1H), 8.45 (dd, J = 5.1, 2.6 Hz, 1H), 8.40 – 8.20 (m, 1H), 7.85 (ddd, J = 17.9, 9.4, 7.3 Hz, 1H), 7.64 (dd, J = 5.1, 2.8 Hz, 1H), 7.53 – 7.30 (m, 1H), 5.30 (s, 2H). 13C NMR (75 MHz, CDCl3) δ 164.49 (s), 163.75 (s), 159.65 (s), 154.75 (s), 149.79 (s), 137.29 (s), 125.41 (s), 121.87 (s), 108.26 (s).
4-(pyridine-2-yl) pyrimidin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(pyridine-2-yl) pyrimidin-2-amine Suppliers
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4-(pyridine-2-yl) pyrimidin-2-amine Spectrum
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