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INDIRUBIN-3-MONOXIME

INDIRUBIN-3-MONOXIME Structure
INDIRUBIN-3-MONOXIME
  • CAS No.667463-82-3
  • Chemical Name:INDIRUBIN-3-MONOXIME
  • CBNumber:CB73571496
  • Molecular Formula:C16H11N3O2
  • Formula Weight:277.28
  • MOL File:667463-82-3.mol
INDIRUBIN-3-MONOXIME Property
  • Boiling point 532.2±50.0 °C(Predicted)
  • Density 1.50±0.1 g/cm3(Predicted)
  • pka 10.69±0.20(Predicted)
  • form Solid
  • color Brown to red
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317
  • Precautionary statements P280-P305+P351+P338

INDIRUBIN-3-MONOXIME Chemical Properties,Usage,Production

  • Uses Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3].
  • Definition ChEBI: Indirubin-3'-monoxime is a member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, an osteogenesis regulator, a neuroprotective agent and an anti-obesity agent. It is a member of oxindoles, a bisindole, a ring assembly, a ketoxime and an alkaloid.
  • in vivo

    Indirubin-3′-oxime (0.05 or 0.5?mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters[3].

    Animal Model:Three-week-old C57BL/6 mice[3]
    Dosage:0.05 or 0.5?mg/kg
    Administration:I.p.; daily for 2 or 10 weeks
    Result:The tibial length of mice increased in a dose-dependent manner.
  • IC 50 JNK1: 0.8 μM (IC50); JNK2: 1.4 μM (IC50); JNK3: 1 μM (IC50); GSK-3β; CDK
  • References [1] Xie Y, et al. Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004;367(3):355-359. DOI:10.1016/j.neulet.2004.06.044
    [2] Hu S, et al. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J Mol Neurosci. 2015;57(4):561-570. DOI:10.1007/s12031-015-0638-y
    [3] Choi S, et al. Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway. Exp Mol Med. 2019;51(9):1-10. Published 2019 Sep 12. DOI:10.1038/s12276-019-0306-3
INDIRUBIN-3-MONOXIME Preparation Products And Raw materials
Raw materials
Preparation Products
INDIRUBIN-3-MONOXIME Suppliers
Global(23)Suppliers
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    TargetMol Chemicals Inc.
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  • Supplier： TargetMol Chemicals Inc.
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INDIRUBIN-3-MONOXIME Spectrum
  • 抑制剂
  • 药靶配体
  • 化合物INDIRUBIN-3'-MONOXIME,10 MM DMSO 溶液
  • 化合物INDIRUBIN-3'-MONOXIME
  • (2Z,3E)-3-(肟基)-[2,3'-联吲哚啉亚基]-2'-酮
  • (2Z,3E)-3-(羟基亚氨基)-[2,3'-联吲哚啉亚基]-2'-酮
  • 667463-82-3
  • Indirubin-3′-oxime, 10 mM in DMSO
  • 2H-Indol-2-one, 3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-
  • (2Z,3E)-3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one

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