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Vincamine

Vincamine Structure
Vincamine
  • CAS No.1617-90-9
  • Chemical Name:Vincamine
  • CBNumber:CB7344925
  • Molecular Formula:C21H26N2O3
  • Formula Weight:354.44
  • MOL File:1617-90-9.mol
Vincamine Property
  • Melting point 232 °C (dec.)(lit.)
  • Boiling point 487.66°C (rough estimate)
  • alpha 42.8 º (c=1 in pyridine)
  • Density 1.1640 (rough estimate)
  • refractive index 1.6500 (estimate)
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly)
  • form Solid
  • pka 12.13±0.40(Predicted)
  • color White to Off-White
  • optical activity [α]23/D +42.8°, c = 1 in pyridine
  • Merck 14,9983
  • Stability Hygroscopic
  • LogP 3.100 (est)
  • EWG's Food Scores 1
  • FDA UNII 996XVD0JHT
  • ATC code C04AX07
  • NIST Chemistry Reference Vincamine(1617-90-9)
  • UNSPSC Code 12352200
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36-26
  • WGK Germany  :3
  • RTECS  :YY8575000
  • HS Code  :29399990
  • Hazardous Substances Data :1617-90-9(Hazardous Substances Data)
  • Toxicity :LD50 in mice (mg/kg): 75 i.v.; >1000 s.c. (Szporny, Szász); 1000 orally (Szabo, Nagy)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P501
Vincamine Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: 75778
  • Product name : Vincamine
  • Purity: analytical standard
  • Packaging: 50MG
  • Price: ₹9504.35
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: V0061
  • Product name : Vincamine
  • Purity: 
  • Packaging: 1G
  • Price: ₹7900
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: V0061
  • Product name : Vincamine
  • Purity: 
  • Packaging: 5G
  • Price: ₹10200
  • Updated: 2022/05/26
  • Buy: Buy

Vincamine Chemical Properties,Usage,Production

  • Description Vincamine is an alkaloid extracted from the leaves of the Vinca minor and is a related synthetic ethyl ester of vincaminic acid. It has spasmolytic effects similar to reserpine and can potentially improve blood flow in the brain.
  • Chemical Properties white to almost white fine crystalline powder
  • Originator Pervancamine ,Dausse,France,1969
  • Uses Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.
  • Definition ChEBI: Vincamine is a vinca alkaloid, an alkaloid ester, an organic heteropentacyclic compound, a methyl ester and a hemiaminal. It has a role as an antihypertensive agent, a vasodilator agent and a metabolite. It is functionally related to an eburnamenine.
  • Manufacturing Process The following route is described in US Patent 4,145,552: At ambient temperature, over a period of thirty minutes, a solution of 33.8g (0.1mol) of (-)-vincadiformine in a mixture of 140 ml of anhydrous dimethylformamide and 140 ml of anhydrous toluene is added to a suspension of 2.64 g (0.11 mol) of sodium hydride in a mixture of 200 ml of anhydrous tetrahydrofuran, 20 ml of anhydrous hexamethylphosphotriamide (EMPT) and 18.7 ml (0.14 mol) of trimethyl phosphite. When the release of hydrogen has finished (about two hours later), the solution is cooled to -10°C and then stirred under an oxygen atmosphere until absorption ceases (duration: 3 hours). Still at -10°C, 136 ml of glacial acetic acid are added, and the mixture is then left at ambient temperature for two hours. After the addition of 500 ml of 1 N sulfuric acid, the aqueous phase is isolated, reextracted with 150 ml of isopropyl ether, made alkaline with 350 ml of 11 N ammonia, then extracted 3 times with 300 ml aliquots of methylene chloride. After drying over calcium chloride and evaporating the solvent, 30.2 g of crude product are obtained which, when chromatographed on a column of silica gel (1.5 kg) yield, 9.9 g of vincamine (yield: 28%) melting point (decomp.): 250°C.
  • brand name Cerebroxine;Cetal;Ocu-vinc;Oxygeron;Pervincamine;Vadicate;Vinca minor;Vincacen;Vincapront;Vincavix;Vincimax.
  • Therapeutic Function Vasodilator
  • World Health Organization (WHO) Vincamine, an alkaloid derived from Vinca minor, is claimed to increase cerebral circulation and utilization of oxygen. It is used in a variety of cerebral disorders and is widely marketed for this purpose.
  • benefits Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and treatment of cerebrovascular disorders and insufficiencies. It has been well documented that antioxidants may contribute to cancer treatment, and thus, vincamine has been investigated recently for its potential antitumor activity. Vincamine was found to show cancer cell cytotoxicity and to modulate several important proteins involved in tumor growth, including acetylcholinesterase (AChE), mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), and T-box 3 (TBX3).
  • General Description Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor L., belonging to the Apocynaceae family.
Vincamine Preparation Products And Raw materials
Raw materials
Preparation Products
Vincamine Suppliers
Global(459)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
Vincamine Spectrum
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  • 長春胺

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