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Azide-PEG3-Desthiobiotin

Azide-PEG3-Desthiobiotin Structure
Azide-PEG3-Desthiobiotin
  • CAS No.1426828-06-9
  • Chemical Name:Azide-PEG3-Desthiobiotin
  • CBNumber:CB73369446
  • Molecular Formula:C18H34N6O5
  • Formula Weight:414.51
  • MOL File:1426828-06-9.mol
Azide-PEG3-Desthiobiotin Property
  • form clear liquid
  • color Colorless to Yellow to Orange
Safety
  • HS Code  :2933.29.9000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Azide-PEG3-Desthiobiotin Price More Price(1)
  • Brand: TCI Chemicals (India)
  • Product number: A3202
  • Product name : Azide-PEG3-Desthiobiotin
  • Purity: 
  • Packaging: 10MG
  • Price: ₹7800
  • Updated: 2022/05/26
  • Buy: Buy

Azide-PEG3-Desthiobiotin Chemical Properties,Usage,Production

  • Description Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd?= 1011?vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.
  • Uses Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azide-PEG3-Desthiobiotin Preparation Products And Raw materials
Raw materials
Preparation Products
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Azide-PEG3-Desthiobiotin Spectrum
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