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Acid-PEG1-t-butyl ester

Acid-PEG1-t-butyl ester Structure
Acid-PEG1-t-butyl ester
  • CAS No.2086689-08-7
  • Chemical Name:Acid-PEG1-t-butyl ester
  • CBNumber:CB73303325
  • Molecular Formula:C10H18O5
  • Formula Weight:218.25
  • MOL File:2086689-08-7.mol
Acid-PEG1-t-butyl ester Property
  • Boiling point 341.9±22.0 °C(Predicted)
  • Density 1.101±0.06 g/cm3(Predicted)
  • solubility Soluble in Water, DMSO, DCM, DMF
  • form Liquid
  • pka 4.27±0.10(Predicted)
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Acid-PEG1-t-butyl ester Chemical Properties,Usage,Production

  • Description Acid-PEG1-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
  • Uses Acid-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 PEGs; Alkyl/ether
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Acid-PEG1-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Acid-PEG1-t-butyl ester Suppliers
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Acid-PEG1-t-butyl ester Spectrum
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