ChemicalBook > CAS DataBase List > 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Structure
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • CAS No.1030825-20-7
  • Chemical Name:2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • CBNumber:CB72603549
  • Molecular Formula:C18H14BrFS
  • Formula Weight:361.27
  • MOL File:1030825-20-7.mol
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Property
  • Melting point 103 °C
  • Boiling point 438.3±40.0 °C(Predicted)
  • Density 1.388
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
  • form Solid
  • color White to Off-White
  • InChI InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
  • InChIKey VLRIERSBZHUCOW-UHFFFAOYSA-N
  • SMILES C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
  • FDA UNII W76HXE3GL5
Safety
  • HS Code  :2934999090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319-H335-H315
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: B5335
  • Product name : 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
  • Purity: min. 98.0 %
  • Packaging: 200MG
  • Price: ₹1800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: B5335
  • Product name : 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
  • Purity: min. 98.0 %
  • Packaging: 1G
  • Price: ₹4400
  • Updated: 2022/05/26
  • Buy: Buy

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Usage,Production

  • Uses 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
  • Synthesis prepares 2-(4-fluorophenyl) thiophene III:
    Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.
    synthesis of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
    Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
    1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials
Raw materials
Preparation Products
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Suppliers
Global(409)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Spectrum
1030825-20-7, 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiopheneRelated Search:
  • 1030825-20-7
  • Pharmaceutical intermediates
  • 系列1
  • 产品-医药产品
  • 高端化学
  • 化工中间体
  • 化工材料
  • 化工原料
  • 化学中间体
  • 杂质对照品
  • 合成材料中间体
  • 对照品-杂质对照品
  • 医药原料
  • 生物化工
  • 卡格列净
  • 医药中间体
  • 坎格列静中间体
  • 坎格列净中间体
  • 噻吩
  • 卡格列净中间体
  • 坎格列净中间体II
  • C18H14BrFS
  • 2-(5-溴-2-甲基苯甲基)-5-(4-氟苯基)噻吩*5
  • CAR-6溴化物/2-[(5-溴-2-甲基苯基)甲基]-5-(4-氟苯基)噻吩
  • 2-(4-氟苯基)-5-[(5-溴-2-甲基苯基)甲基]噻吩2-(5-BROMO-2-METHYLBENZYL)-5-(4-FLUOROPHENYL)THIOPHENE
  • 卡格列净INT
  • 卡格列净杂质603
  • 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩(卡格列净杂质)
  • 卡那列净杂质69
  • 2-(甲基-5-溴卞基)-5-(4-氟苯)噻吩
  • 3-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
  • 卡格列净杂质52
  • 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩(坎格列净中间体) 1KG
  • CAR-6溴化物
  • 2-[(5-溴-2-甲基苯基)甲基]-5-(4-氟苯基)噻吩
  • 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
  • 坎格列净 中间体4
  • 2-(5-溴-2-甲基苯基)-5-(4-氟苯基)噻吩
  • 卡格列净中间体4
  • 坎格列净中间体1
  • 2-(2-甲基-5-溴苄基-5-(4-氟苯))噻吩 (卡格列净中间体)
  • 卡格列净中间体(CAR-6溴化物)
  • 2-(4-氟苯基)-5-((5-溴-2-甲基苯基)甲基)噻吩
  • 2-(5-溴-2-甲基-苄基)-5 -(4-氟-苯基)-噻吩
  • 2-(5-溴-2-甲基苯基)-5-(4-氟苯)噻吩
  • 2-(4-氟苯)-5-(5-溴-2-甲基苄基)噻吩
  • 2-(5-溴-2-甲基苯甲基)-5-(4-氟苯基)噻吩
  • 1030825-20-7
  • 2-(2-Methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene
  • Kagliflozin impurity 24
  • 2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t
  • 2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene
  • CAGLIFLOZIN IMPURITY C
  • CanagliflozinINT
  • 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio
  • 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
  • Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C
  • canagliflozin impurities1

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