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Ramiprilat

Ramiprilat Structure
Ramiprilat
  • CAS No.87269-97-4
  • Chemical Name:Ramiprilat
  • CBNumber:CB7231407
  • Molecular Formula:C21H28N2O5
  • Formula Weight:388.46
  • MOL File:87269-97-4.mol
Ramiprilat Property
  • Melting point 139-141°C
  • Boiling point 632.2±55.0 °C(Predicted)
  • Density 1.273±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,2-8°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 2.20±0.10(Predicted)
  • color White to Pale Yellow
  • Stability Hygroscopic
  • FDA UNII 6N5U4QFC3G
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Ramiprilat Chemical Properties,Usage,Production

  • Description Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.
  • Chemical Properties White to Off-White Solid
  • Uses A metabolite of Ramipril (R111000).
  • Uses Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)
  • Definition ChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
  • in vitro pretreatment with ramiprilat could significantly attenuate the recovery of b2 kinin receptors in while increasing that from membranes lacking caveolin, and such effect was not because of the inhibition of bradykinin degradation. ramiprilat could also decrease [3h]bradykinin binding to cr membranes. in addition, ramiprilat treatment led to reactivation of the b2 receptor in bradykinin-stimulated cells [1].
  • in vivo in previous animal study, when compared with the control rats, diabetic rats showed decreased creatinine clearance rate, increased urinary protein excretion and blood pressure, as well as development of tubulointerstitial fibrosis, glomerulosclerosis, and inflammatory cell infiltration. furthermore, the blocking angiotensin ii with ramipril (the prodrug of ramiprilat) was able to significantly improve all of these parameters [2].
  • References [1] t. benzing, i. fleming, a. blaukat, et al. angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the b2 kinin receptor within the plasma membrane of native endothelial cells. circulation 99(15), 2034-2040 (1999).
    [2] li c, yang cw, park cw, ahn hj, kim wy, yoon kh, suh sh, lim sw, cha jh, kim ys, kim j, chang ys, bang bk. long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. kidney int. 2003 feb;63(2):454-63.
    [3] warner gt, perry cm. ramipril: a review of its use in the prevention of cardiovascular outcomes. drugs. 2002;62(9):1381-405.
Ramiprilat Preparation Products And Raw materials
Raw materials
Preparation Products
Ramiprilat Suppliers
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Ramiprilat Spectrum
87269-97-4, RamiprilatRelated Search:
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  • 38846
  • C21H28N2O5
  • 雷米普利杂质27
  • 雷米普利杂质1 (雷米普利EP杂质E)
  • 雷米普利杂质1(EP杂质E)
  • 雷米普利EP杂质E(雷米普利)
  • 雷米普利1
  • (2S,3AS,6AS)-1-((S)-2-(((S)-1-羧基-3-苯丙基)氨基)丙酰基)八氢环戊二烯并[B]吡咯-2-羧酸
  • 雷米普利代谢物
  • 雷米普利RAMIPRILAT (RAMIPRIL DIACID)
  • 雷米普利欧洲药典杂质 E
  • 雷米普利杂质E (EP)
  • 雷米普利二酸
  • 雷米普利杂质Ⅴ(雷米普利拉)
  • 雷米普利杂质Ⅴ（雷米普利拉）
  • 雷米普利EP杂质E(雷米普利特)
  • 雷米普利
  • (2S,3AS,6AS)-1-((S)-N-((S)-1-羧基-3-苯基丙基)丙氨酰)四氢环戊并[B]吡咯-2-羧酸
  • 雷米普利EP杂质E
  • 雷米普利拉
  • 87269-97-4
  • Ramipril Impurity 27
  • RAMIPRIL USP
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole
  • (2S,3aS,6aS)-1-(((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • RamiprilEPImpurityE-d5
  • Ramipril impurity Ⅴ (Ramiprilat)
  • Ramipril EP Impurity EQ: What is Ramipril EP Impurity E Q: What is the CAS Number of Ramipril EP Impurity E Q: What is the storage condition of Ramipril EP Impurity E Q: What are the applications of Ramipril EP Impurity E
  • Ramipley
  • Ramipril EP Impurity E (Ramipril Diacid/ Ramiprilat)
  • Ramipril Impurity 1 （EP Impurity E）
  • Ramiprilat USP/EP/BP
  • Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,6aS)-
  • Ramipril impurity Ⅴ(Ramiprilat)
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Car
  • Ramipril Impurity 1(Ramipril EP Impurity E)
  • (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • Ramipril EP Imp E (acid)
  • Ramipril Impurity V:Ramiprilat
  • Ramipril EP Impurity E (Ramiprilat)
  • RaMipril EP IMpurity E
  • RaMipril IMpurity-E (EP)
  • (2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • ramiprilat:(2s,3as,6as)-1-((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta(b)pyrrole-2-carboxylic acid
  • Ramiprilate
  • (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-Carboxy-3-phenylpropyl]amino]propionyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid
  • (2S,3aS,6aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

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