ChemicalBook > CAS DataBase List > 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Structure
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • CAS No.981-34-0
  • Chemical Name:9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • CBNumber:CB72129663
  • Molecular Formula:C22H28O5
  • Formula Weight:372.45
  • MOL File:981-34-0.mol
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Property
  • Melting point 210-220 ºC
  • Boiling point 564.9±50.0 °C(Predicted)
  • Density 1.32±0.1 g/cm3(Predicted)
  • vapor pressure 0-357.304Pa at 25℃
  • storage temp. Refrigerator
  • solubility Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
  • form Solid
  • pka 12.56±0.70(Predicted)
  • color White to Light Beige
  • InChIKey GBDXNHBVYAMODG-OBDZOPJXNA-N
  • SMILES C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|
  • FDA UNII M9AY9BSI41
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

  • Description 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.
  • Chemical Properties Off-White Solid
  • Uses 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.
  • Preparation Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
    9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • Toxics Screening Level The initial threshold screening level (ITSL) for betamethasone 11 is 17 μg/m3 based on an annual averaging time.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials
Raw materials
Preparation Products
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Spectrum
981-34-0, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Related Search:
  • 981-34-0
  • Steroids
  • Pharmaceuticals
  • Metabolites & Impurities
  • Intermediates & Fine Chemicals
  • 生化试剂
  • 标准品
  • 甾体类原料中间体
  • 甾体类原料-糖皮质激素
  • 医用原料
  • 杂质对照品
  • 日用化学品
  • 化学试剂
  • 化合物
  • 激素中间体
  • 生殖激素原料药中间体
  • 医用原料
  • 原料药
  • 医药原料
  • 氨基酸
  • 二丙酸倍氯米松EP杂质R(倍他米松9,11-环氧乙烷)
  • 二丙酸倍氯米松 EP 杂质 R(倍他米松 9,11-环氧化物)
  • 倍氯米松杂质15(丙酸倍氯米松EP杂质R)
  • 9B,11B-环氧-16B-甲基孕甾-1,4-二烯-17A,21-二醇-3,20-二
  • 倍氯米松杂质15(BECLOMETASONEDIPROPIONATEEP杂质R)
  • 倍他米松杂质5(倍他米松EP杂质E)
  • 丙酸倍氯米松EP杂质R(倍他米松9,11-环氧化物)
  • 倍他米松9,11-环氧化物(丙酸倍氯米松EP杂质R)
  • 丙酸倍氯米松EP杂质R(倍他米松EP杂质E)
  • 倍他米松中间体
  • 倍他米松杂质E
  • 二丙酸倍氯米松EP杂质R
  • 丙酸倍氯米松EP杂质R
  • 倍氯米松双丙酸酯杂质1
  • 倍氯米松9,11-环氧化物(倍他米松9,11-环氧化物)
  • 倍他米松E
  • 倍他米松杂质E(EP) 标准品
  • 倍他米松杂质6
  • 倍他米松相关化合物E(USP)
  • 倍他米松杂质E(EP)
  • 倍他米松 9,11-环氧化物
  • 倍他米松EP杂质E
  • 倍氯米松双丙酸酯EP杂质R
  • DB11,倍他米松环氧水解物
  • 9b,11b-环氧-16b-甲基孕甾-1,4-二烯-17a,21-二醇-3,20-二酮
  • 倍他米松环氧物
  • 倍他米松环氧水解物(DB11)
  • 9B,11B-环氧-16B-甲基孕甾-1,4-二烯-17A,21-二醇-3,20-二酮 10G
  • 倍他米松环氧
  • 倍他米松9,11环氧
  • 9,11-环氧倍他米松
  • 981-34-0
  • Betamethasone Epoxide Hydrolyzate
  • 9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione
  • Beclometasone Impurity R
  • Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Betamethasone epoxide hydrolase
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

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