Chemical Properties
Salicylohydrazide, also known as 2-Hydroxybenzohydrazide, is a white to off-white crystalline powder or pale yellow crystals. It is stable under standard temperature and pressure, soluble in ethanol and methanol, and should be protected from contact with oxidizing agents.
Uses
A novel colorimetric probe, CDAH, was designed and synthesized using a coumarin derivative as the fluorescent moiety and salicylhydrazide as the ligand through a Schiffs reaction.[2]
Application
2-hydroxybenzohydrazide is a useful research chemical.
Preparation
The preparation of salicylhydrazide was carried out according to the literature. To a solution of methyl salicylate (0.1 mol, 13.81 g) in 30 mL of absolute alcohol in a 150 mL three-neck flask, hydrazine hydrate (30 mL, 80%) was added. The reaction mixture was then heated to reflux for 4 hours. Next, the excess absolute alcohol was completely removed under reduced pressure. The residue was recrystallized from water to yield salicylhydrazide.[1]
References
[1] Meng, D., Liu, F., Li, Y., Yang, Z., Li, G., & Guo, D. (2015). Synthesis, characterization and properties of salicylhydrazide–salicylacylhydrazone derivatives and their terbium complexes.
Luminescence,
31 2, 507–514.
https://doi.org/10.1002/bio.2989
