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3-Bromopropionic acid

CAS No.590-92-1
Chemical Name:3-Bromopropionic acid
CBNumber:CB7177280
Molecular Formula:C3H5BrO2
Formula Weight:152.97
MOL File:590-92-1.mol

3-Bromopropionic acid Property

Melting point 58-62 °C(lit.)
Boiling point 140-142 °C (45 mmHg)
Density 1.48 g/mL at 25 °C(lit.)
refractive index 1.4753 (estimate)
Flash point 150 °F
storage temp. 2-8°C
solubility H₂O: 0.1 g/mL, clear
form Crystals or Crystalline Powder
pka 4.00(at 25℃)
color White to slightly yellow
Water Solubility 0.1 g/mL
Merck 14,1433
BRN 1071333
Dielectric constant 11.0（20℃）
CAS DataBase Reference 590-92-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII WFZ7CSR69R
NIST Chemistry Reference Propanoic acid, 3-bromo-(590-92-1)
EPA Substance Registry System Propanoic acid, 3-bromo- (590-92-1)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :F,C
Risk Statements :11-34
Safety Statements :26-36/37/39-45
RIDADR :UN 3261 8/PG 2
WGK Germany :3
RTECS :UE7875000
Hazard Note :Corrosive/Highly Flammable
TSCA :Yes
HazardClass :4.1
PackingGroup :III
HS Code :29159080
Hazardous Substances Data :590-92-1(Hazardous Substances Data)

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314
Precautionary statements P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

3-Bromopropionic acid Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: 101281
Product name : 3-Bromopropionic acid
Purity: 97%
Packaging: 100G
Price: ₹4390
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-A11573-36
Product name : 3-Bromopropionic acid, 97%
Purity:
Packaging: 500g
Price: ₹10751
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: B0645
Product name : 3-Bromopropionic Acid
Purity: min. 98.0 %
Packaging: 25G
Price: ₹2100
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A11573-22
Product name : 3-Bromopropionic acid, 97%
Purity:
Packaging: 100g
Price: ₹3647
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B0645
Product name : 3-Bromopropionic Acid
Purity: min. 98.0 %
Packaging: 100G
Price: ₹4000
Updated: 2022/05/26
Buy: Buy

3-Bromopropionic acid Chemical Properties,Usage,Production

Chemical Properties white to pale yellow or orange crystalline. soluble in water, alcohol, ether, chloroform, benzene. Hydrolysis in alkaline solution generates hydroxypropionic acid. Corrosive. for organic synthesis.
Uses 3-Bromopropionic acid used as quaternization agent in amperometric biosensors.
Application 3-Bromopropionic acid is a widely used chemical intermediate. It can be used as a starting material to synthesize derivatives such as esters, acid halides and amides; the active group bromine can undergo a series of reactions, and is mainly used in the fields of pesticides and medicines. Such as the pesticides diflufenacil, furalax and so on.
Preparation 3-Bromopropionic acid is prepared by reacting acrylonitrile with hydrogen bromide to obtain bromopropionitrile and then hydrolyzing it. Add acrylonitrile to boiling hydrobromic acid, reflux at 130°C for 6 hours, extract the solid obtained by filtration with ethanol, and obtain the crude product after recovering ethanol by distillation under reduced pressure. By heating 2-cyanoethanol and 40% hydrobromic acid to reflux for 2h, 3-bromopropionic acid can also be produced with a yield of over 80%.
Synthesis Reference(s) Journal of the American Chemical Society, 71, p. 2807, 1949 DOI: 10.1021/ja01176a061
Organic Syntheses, Coll. Vol. 1, p. 131, 1941
Safety Profile Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.
Purification Methods The acid crystallises as plates from CCl4. It is soluble in organic solvents and H2O. Its methyl ester has b 65o/18mm and 80o/27mm. The S-benzylisothiouronium salt has m 136o. [Kendall & McKenzie Org Synth Coll Vol I 131 1941, Beilstein 2 IV 764.]