ignavine

ignavine Structure
ignavine
  • CAS No.1357-76-2
  • Chemical Name:ignavine
  • CBNumber:CB71342456
  • Molecular Formula:C27H31NO5
  • Formula Weight:449.54
  • MOL File:1357-76-2.mol
ignavine Property
  • Melting point 226-8°C
Safety
  • Toxicity :LD50 oral in mouse: > 500mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
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ignavine Chemical Properties,Usage,Production

  • Description This aconitine alkaloid is present in several A conitum species indigenous to Japan, e.g. Aconitum calliantum Koidzumi, A. grossedentatum, Nakai, A. hakusanense Nakai, A. kamtschaticum Willd. et Reichb., A. lucidusculum Nakai, A. senanense Nakai, A. subcuneatum Nakai, A. tortuosum Willd. and A. Zuccarini Nakai. It yields clusters of colourless needles when crystallized from Me2COMeOH and gives a form, m.p. 172-4 °c in addition to the one having the above melting point. It is dextrorotatory with [α]29D~} + 85.27° (MeOH), or [α]14D + 92.98°. Crystalline salts of the alkaloid have been prepared, e.g. the hydrochloride, m.p. 245-6°C (dec.); hydrobromide, m.p. 260-2°C (dec.) and the nitrate which crystallizes as the monohydrate, m.p. 220-2°C (dec. dry). Alkaline hydrolysis furnishes benzoic acid and hydroignavinol, C20H2S04N, m.p. 302°C.
  • References Ochiai et al., J. Pharm. Soc., Japan, 72, 816 (1952) Ochiai et al., ibid, 76, 550 (1956) Ochiai", Okamoto, Sasaki., ibid, 75,545 (1955) Ochiai et al., Chem. Pharm. Bull., 6,327 (1958) Ochiai et al., ibid, 8, 976 (1960) Pelletier., Tetrahedron, 14,103 (1961)
ignavine Preparation Products And Raw materials
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ignavine Spectrum
1357-76-2, ignavineRelated Search:
  • 1357-76-2
  • Hetisan-2,3,9,15-tetrol, 2-benzoate, (2α,3β,15β)- (9CI)
  • Hetisan-2α,3β,9,15β-tetrol 2-benzoate
  • ignavine

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