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CCK-B Receptor Antagonist 2

CCK-B Receptor Antagonist 2 Structure
CCK-B Receptor Antagonist 2
  • CAS No.155412-88-7
  • Chemical Name:CCK-B Receptor Antagonist 2
  • CBNumber:CB65821330
  • Molecular Formula:C27H28N6O3
  • Formula Weight:484.55
  • MOL File:155412-88-7.mol
CCK-B Receptor Antagonist 2 Property
  • Boiling point 725.1±60.0 °C(Predicted)
  • Density 1.29±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO: 250 mg/mL (515.94 mM)
  • pka 11.35±0.40(Predicted)
  • form Solid
  • color White to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

CCK-B Receptor Antagonist 2 Chemical Properties,Usage,Production

  • Uses CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].
  • in vivo

    CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1].

  • IC 50 CCKBR
  • References [1] Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41. DOI:10.1021/jm960669+
CCK-B Receptor Antagonist 2 Preparation Products And Raw materials
Raw materials
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CCK-B Receptor Antagonist 2 Spectrum
  • 抑制剂
  • 化合物 CCK-B RECEPTOR ANTAGONIST 2
  • 化合物 T10707
  • 155412-88-7
  • Urea, N-(3-aminophenyl)-N'-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-
  • CCK B Receptor Antagonist 2,CCKB Receptor Antagonist 2
  • CCK-B Receptor Antagonist 2

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