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Belvarafenib

Belvarafenib Structure
Belvarafenib
  • CAS No.1446113-23-0
  • Chemical Name:Belvarafenib
  • CBNumber:CB64806091
  • Molecular Formula:C23H16ClFN6OS
  • Formula Weight:478.93
  • MOL File:1446113-23-0.mol
Belvarafenib Property
  • Boiling point 609.6±55.0 °C(Predicted)
  • Density 1.562±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C(protect from light)
  • solubility DMSO:46.17(Max Conc. mg/mL);96.4(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM)
    DMF:30.0(Max Conc. mg/mL);62.64(Max Conc. mM)
  • form A crystalline solid
  • pka 11.16±0.43(Predicted)
  • color Off-white to yellow
  • FDA UNII 31M3WLJ3KG
  • NCI Drug Dictionary belvarafenib
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

Belvarafenib Chemical Properties,Usage,Production

  • Uses Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].
  • IC 50 BRafV600E: 7 nM (IC50); CRAF: 5 nM (IC50); B-Raf: 56 nM (IC50)
  • References [1] WO 2013/100632 A1.
Belvarafenib Preparation Products And Raw materials
Raw materials
Preparation Products
Belvarafenib Suppliers
Global(65)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
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    Career Henan Chemica Co
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    Aladdin Scientific
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Belvarafenib Spectrum
1446113-23-0, BelvarafenibRelated Search:
  • 化学试剂
  • 高纯试剂
  • 抑制剂
  • 合成有机化合物配体
  • C23H16ClFN6OS
  • 化合物BELVARAFENIB,10 MM DMSO 溶液
  • 4-氨基-N-[1-[(3-氯-2-氟苯基)氨基]-6-甲基-5-异喹啉基]噻吩并[3,2-D]嘧啶-7-甲酰胺
  • BELVARAFENIB(HM95573)
  • 4-氨基-N-(1-((3-氯-2-氟苯基)氨基)-6-甲
  • 4-氨基-N-(1-((3-氯-2-氟苯基)氨基)-6-甲基异喹啉-5-基)噻吩并[3,2-D]嘧啶-7-甲酰胺
  • 化合物BELVARAFENIB
  • 1446113-23-0
  • Belvarafenib, 10 mM in DMSO
  • Tovorafenib?(DAY-101)
  • RG-6185
  • RG6185
  • RG 6185
  • HM-95573
  • HM95573
  • HM 95573
  • GDC-5573
  • GDC5573
  • GDC 5573
  • Belvarafenib（HM95573）
  • Belvarafenib (GDC-5573)
  • RG-6185,Belvarafenib,inhibit,GDC-5573,HM 95573,GDC 5573,Inhibitor,RG6185,RG 6185,HM95573,HM-95573,GDC5573,Raf kinases,Raf
  • Belvarafenib (GDC-5573, HM-95573, RG-6185)
  • Thieno[3,2-d]pyrimidine-7-carboxamide, 4-amino-N-[1-[(3-chloro-2-fluorophenyl)amino]-6-methyl-5-isoquinolinyl]-
  • 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
  • Belvarafenib

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