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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL

Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Structure
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
  • CAS No.170116-63-9
  • Chemical Name:Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
  • CBNumber:CB6480325
  • Molecular Formula:C20H28N2O5
  • Formula Weight:376.45
  • MOL File:Mol file
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Property
  • Boiling point 522.5±50.0 °C(Predicted)
  • Density 1.214±0.06 g/cm3(Predicted)
  • storage temp. -15°C
  • pka -1.00±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Chemical Properties,Usage,Production

  • Uses Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].
  • IC 50 PREP: 12 nM (IC50)
  • References [1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
    [2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial?and?THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Preparation Products And Raw materials
Raw materials
Preparation Products
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Spectrum
170116-63-9, Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETALRelated Search:
  • 多肽
  • 170116-63-9
  • 1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-
  • Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL

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