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1-isothiocyanato-PEG3-Azide

1-isothiocyanato-PEG3-Azide Structure
1-isothiocyanato-PEG3-Azide
  • CAS No.1310686-23-7
  • Chemical Name:1-isothiocyanato-PEG3-Azide
  • CBNumber:CB63162806
  • Molecular Formula:C9H16N4O3S
  • Formula Weight:260.31
  • MOL File:1310686-23-7.mol
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1-isothiocyanato-PEG3-Azide Chemical Properties,Usage,Production

  • Uses 1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1-Isothiocyanato-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • Biological Activity 1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
  • IC 50 PEGs
  • References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
1-isothiocyanato-PEG3-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
1-isothiocyanato-PEG3-Azide Suppliers
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1-isothiocyanato-PEG3-Azide Spectrum
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