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MMAF-OMe

MMAF-OMe Structure
MMAF-OMe
  • CAS No.863971-12-4
  • Chemical Name:MMAF-OMe
  • CBNumber:CB63154034
  • Molecular Formula:C40H67N5O8
  • Formula Weight:746
  • MOL File:863971-12-4.mol
MMAF-OMe Property
  • Boiling point 871.8±65.0 °C(Predicted)
  • Density 1.095±0.06 g/cm3(Predicted)
  • pka 13.89±0.46(Predicted)
  • form Solid
  • color Off-white to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

MMAF-OMe Chemical Properties,Usage,Production

  • Uses MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
  • IC 50 Auristatin
  • References [1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881
MMAF-OMe Preparation Products And Raw materials
Raw materials
Preparation Products
MMAF-OMe Suppliers
Global(39)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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    ChemExpress
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    TargetMol Chemicals Inc.
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    Protheragen-ING
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    Aladdin Scientific
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  • Supplier： MedChemexpress LLC
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  • Supplier： Tianjin Chempharmatech Co.,Ltd.
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MMAF-OMe Spectrum
  • 高端化学
  • 定做
  • 抑制剂
  • 细胞生物学试剂
  • 化合物MMAF-OME,10 MM DMSO 溶液
  • ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-二甲基-2-((S)-3-甲基-2-(甲氨基)丁酰氨基))丁酰氨基)-3-甲氧基-5-甲基庚酰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酰基)-L-苯丙氨酸甲酯
  • MMAF-OME,TUBULIN抑制剂
  • 一甲基澳瑞他汀F甲酯
  • N-甲基-L-缬氨酰-L-缬氨酰-(3R,4S,5S)-3-甲氧基-5-甲基-4-(甲基氨基)庚酰-(ΑR,ΒR,2S)-Β-甲氧基-Α-甲基 -2-吡咯烷丙酰基-L-苯丙氨酸甲酯
  • 化合物MMAF-OME
  • MMAF-OME甲酯
  • 863971-12-4
  • MMAF-OMe, 10 mM in DMSO
  • Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate
  • ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin
  • L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
  • MONOMETHYL AURISTATIN F METHYL ESTER
  • MMAF-OMe

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