Fimaporfin (TPCS2a) is a photosensitizer that localizes to endosomes/lysosomes with an excitation wavelength of 420 nm and an emission wavelength between 640 and 680 nm[1][2].
References
[1] Kaja Lund, et al. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin. J Exp Clin Cancer Res. 2017 Dec 19;36(1):187. DOI:10.1186/s13046-017-0662-6 [2] Enzian P, et al. Photochemical internalization with fimaporfin: enhanced bleomycin treatment for head and neck cancer[J]. Pharmaceutics, 2023, 15(8): 2040. DOI:10.3390/pharmaceutics15082040
