ChemicalBook > CAS DataBase List > (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Structure
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • CAS No.1012341-50-2
  • Chemical Name:(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • CBNumber:CB62723688
  • Molecular Formula:C23H29NO4
  • Formula Weight:383.48
  • MOL File:1012341-50-2.mol
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Property
  • Melting point 145-147°C
  • Boiling point 582.6±50.0 °C(Predicted)
  • Density 1.115±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
  • pka 4?+-.0.23(Predicted)
  • form Solid
  • color White to Off-White
  • InChI InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
  • InChIKey YNELJETWNMPEEH-OXDNQSQGNA-N
  • SMILES C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |&1:3,6,r|
  • FDA UNII FJ7AWX8DMF
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemical Properties,Usage,Production

  • Description (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid is a pharmaceutical intermediate compound that can be used to synthesize Sacubitril, a neprilysin inhibitor used as an adjuvant drug in combination with valsartan to reduce the risk of cardiovascular death and heart failure hospitalization in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction.
  • Uses (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid is a useful building block in the synthesis of various pharmaceuticals. Could be useful for treating bacterial infectious disease.
  • Synthesis Dissolve 2g [Ru] catalyst (diiodo(p-cymene) ruthenium(II) dimer) and 1.3g (R,R)-Me-Duphos in 20mL toluene, and react at 65-70 for one hour , Prepared as a chiral catalyst. Add the toluene solution of the above chiral catalyst into a clean hydrogenation kettle, and sequentially add SM1 (763g), 202g triethylamine, and 16L methanol solvent, and then seal the hydrogenation kettle to replace the nitrogen for three times and then replace the hydrogen for three times (0.4-0.5MPa) The reaction was carried out at 55°C for 12 hours under pressure, and the reaction liquid was taken for liquid phase detection. The conversion rate of reaction SM1 reached 99.99%. The reaction solution is filtered and concentrated, and the pure (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid can be obtained by beating with n-hexane and ethyl acetate (1:1); the yield is 96.1%, and the product is an off-white solid.
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Suppliers
Global(416)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Spectrum
1012341-50-2, (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acidRelated Search:
  • 1012341-50-2
  • 032-LCZ696
  • LCZ696
  • intermediate
  • intermediates
  • 1
  • 化工原料及中间体
  • 高端化学
  • 合成材料中间体
  • 原料药
  • 化学试剂
  • 有机化学
  • 化工中间体
  • 化工原料
  • 有机化工原料
  • 抗高血压
  • 医药原料
  • 化工中间体
  • 杂质对照品
  • 医药中间体
  • LCZ696中间体
  • LCZ696 中间体
  • (2R,4S)-5-([1,1'-联苯]-4-基)-4-((叔丁氧羰基)氨基)-2-甲基戊酸
  • 沙库巴曲缬沙坦杂质52
  • LCZ696杂质547-06对照品
  • ENTRESTO中间体
  • 沙库必曲(LCZ696)杂质17
  • 沙库巴曲杂质27
  • 沙库巴曲钙杂质24
  • LCZ696中间体-1,(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧羰基)氨基]-2-甲基戊酸
  • LCZ696中间体1/(R)-叔丁基 (1-([1,1'-联苯]-4-基)-3-羟基丙烷-2-基)氨基甲酸酯
  • SVS-IM5-Z1
  • (2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸/(2R,4S)-5-([1,1'-BIPHENYL]-4-YL)-4-((TERT-BUTOXYCARBONYL)AMINO)-2-METHYLPENTANOIC ACID
  • LCZ-696中间体40
  • 沙库必曲-须沙坦水合物
  • LCZ696杂质123
  • LCZ696杂质547-06
  • 沙库比曲缬沙坦(LCZ696)中间体
  • 缬沙坦杂质80
  • 沙库巴曲缬沙坦中间体
  • (2R,4S)-5-([1,1'-联苯]-4-基)-4-((叔丁氧羰基)氨基)-2-甲基戊酸 中文名称 (2R,4S)-5-([1,1'-联苯]-4-基)-4-((叔丁氧羰基)氨基)-2-甲基戊酸 英
  • LCZ696中间体,(2R,4S)-5-([1,1'-联苯]-4-基)-4-((叔丁 氧羰基)氨基)-2-甲基戊酸
  • (2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨]-2-甲基戊酸
  • ((S)-N-戊酰基-{[2-(1H-四唑-5-基)-联苯-4-基]-甲基}-缬氨酸)((2R,4S)-5-(联苯-4-基)-4-(氨基)-5-(3-羧基-丙酰基氨基)-2-甲基-戊酸乙酯)三钠半五水合物
  • 沙库比曲缬沙坦/LCZ696中间体/(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸
  • (2R,4S)-5-(BIPHENYL-4-YL)-4-[(TERT-BUTOXYCARBONYL)AMI O]-2-METHYLPENTANOIC ACID(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸[DMF NO. 031502]
  • 沙库比曲缬沙坦/(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸
  • SACUBITRIL 杂质8
  • 沙必比尔杂质8
  • (2R,4S)-5-(4-联苯基)-4-(BOC-氨基)-2-甲基戊酸
  • LCZ696 中间体N-3
  • 塞克比曲标准品-SS
  • (2R,4S)-5-(联苯-4-基)-4-[（叔丁氧羰基）氨基]-2-甲基戊酸
  • LCZ696 医药中间体Ⅰ
  • 4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸
  • 2-氯噻吩-5-甲酸(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸
  • LCZ696-50-2中间体
  • LCZ-696中间体40(R,R)

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