EP1 Receptor Polyclonal Antibody

Description

The biological effects of PGE2 are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.1,2 Binding of PGE2 to the EP1 receptor results in an increase in phosphatidyl inositol turnover with subsequent increase in intracellular free Ca2+.3,4 Pharmacologically, EP1 receptors mediate contraction of smooth muscle.1 The human EP1 receptor is comprised of 402 amino acids with a molecular mass of approximately 42,000.3 The EP1 receptor is expressed in a variety of tissues, including the kidney, lung, and sensory neuron.3,4,5 Within the kidney, the EP1 receptor is expressed at high levels in the cortical, outer medullary, and inner medullary collecting duct.6WARNING This product is not for human or veterinary use.