Exendin (5-39)
- Product NameExendin (5-39)
- CAS196109-27-0
- CBNumberCB6186087
- MW0
- MDL NumberMFCD01634833
- MOL FileMol file
Chemical Properties
| form | Solid |
| color | White to off-white |
| Sequence | Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
Exendin (5-39) Chemical Properties,Usage,Production
Uses
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].in vivo
Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1].
| Animal Model: | Wistar rats (3 weeks old and 18 days pregnant)[1] |
| Dosage: | 0.3 μg |
| Administration: | Intracerebroventricular injection; 0.3 μg; once daily; 1-week |
| Result: | Inhibited GLT-1 protein levels and inhibited long-term depression in rats. |
References
[1] Kazuma Kobayashi, et al. Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. 2013 Apr 10;1505:1-10. DOI:10.1016/j.brainres.2013.01.012Exendin (5-39) Suppliers
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