Description
10(E),12(Z)-Conjugated linoleic acid-d7 is intended for use as an internal standard for the quantification of 10(E),12(Z)-conjugated linoleic acid (Item No. 90145) by GC- or LC-MS. 10(E),12(Z)-Conjugated linoleic acid is an isomer of linoleic acid (Item Nos. 90150 | 21909 | 90150.1) that has been found in bovine milk products.1 It binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 200 nM) and activates PPARα in a reporter assay using COS-1 cells expressing the mouse receptor.2 10(E),12(Z)-Conjugated linoleic acid also inhibits stearoyl-CoA desaturase activity in mouse liver microsomes and tartrate-resistant acid phosphatase (TRAP) activity in media from primary human CD14+ monocytes.3,4 It induces apoptosis in LoVo and HT-29 colon cancer cells when used at a concentration of 100 µM.5 10(E),12(Z)-Conjugated linoleic acid reduces epididymal, perirenal, and subcutaneous white adipose tissue weights in hamsters fed an atherogenic diet.6WARNING This product is not for human or veterinary use.
References
[1] RONALDO OLIVEIRA. Fatty Acid Profile of Milk and Cheese from Dairy Cows Supplemented a Diet with Palm Kernel Cake.[J]. Molecules, 2015, 20 8: 15434-15448. DOI:
10.3390/molecules200815434[2] S Y MOYA-CAMARENA. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha.[J]. Journal of Lipid Research, 1999, 40 8: 1426-1433.
[3] YEONHWA PARK . Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2000, 1486 2: Pages 285-292. DOI:
10.1016/s1388-1981(00)00074-3[4] ILANA PLATT Ahmed E S. Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes.[J]. Lipids in Health and Disease, 2009, 8: 15. DOI:
10.1186/1476-511x-8-15[5] KUI-JIN KIM. ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells.[J]. Biomolecules & Therapeutics, 2015, 23 2: 134-140. DOI:
10.4062/biomolther.2014.107[6] EDURNE SIMÓN. trans-10,cis-12 Conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters[J]. Journal of Nutritional Biochemistry, 2006, 17 2: Pages 126-131. DOI:
10.1016/j.jnutbio.2005.06.001
