ChemicalBook > CAS DataBase List > CORTICOTROPIN RELEASING FACTOR ANTAGONIST
CORTICOTROPIN RELEASING FACTOR ANTAGONIST
- CAS No.90880-23-2
- Chemical Name:CORTICOTROPIN RELEASING FACTOR ANTAGONIST
- CBNumber:CB61472927
- Molecular Formula:C166H274N46O53S2
- Formula Weight:0
- MOL File:Mol file
CORTICOTROPIN RELEASING FACTOR ANTAGONIST Property
- storage temp. Desiccate at -20°C
- solubility Soluble to 1 mg/ml in 0.1% TFA
- form Powder
- color White to off-white
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
CORTICOTROPIN RELEASING FACTOR ANTAGONIST Chemical Properties,Usage,Production
- Uses α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].
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References
[1] Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6. DOI:10.1007/s00213-003-1403-4
[2] Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. DOI:10.1016/s0014-2999(99)00506-3
CORTICOTROPIN RELEASING FACTOR ANTAGONIST Preparation Products And Raw materials
Raw materials
Preparation Products
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90880-23-2, CORTICOTROPIN RELEASING FACTOR ANTAGONISTRelated Search:
- ADRENOMEDULLIN (16-31) (HUMAN, PIG) PAMP-12 (human, porcine) ADRENOMEDULLIN (22-52) (HUMAN) H-GLU-LEU-ARG-MET-SER-SER-SER-TYR-PRO-THR-GLY-LEU-ALA-ASP-VAL-LYS-ALA-GLY-PRO-ALA-GLN-THR-LEU-ILE-ARG-PRO-GLN-ASP-MET-LYS-GLY-ALA-SER-ARG-SER-PRO-GLU-ASP-SER-SER-PRO-ASP-ALA-ALA-ARG-ILE-ARG-VAL-OH TRIFLUOROACETATE ADRENOMEDULLIN (13-52) (HUMAN) H-LYS-TRP-ASN-LYS-TRP-ALA-LEU-SER-ARG-NH2 ACTH (22-39) ADRENOMEDULLIN (RAT)
- 多肽合成
- 药靶配体
- 目录多肽
- Α-HELICAL CRF 9-41,CRF2 受体拮抗剂
- 肾上腺皮质素释放因子多肽Α-HELICAL CRF(9-41)
- 90880-23-2
