ChemicalBook > CAS DataBase List > Diphenylpiperidin-4-ylmethanol hydrochloride
Diphenylpiperidin-4-ylmethanol hydrochloride
Diphenylpiperidin-4-ylmethanol hydrochloride
- CAS No.1798-50-1
- Chemical Name:Diphenylpiperidin-4-ylmethanol hydrochloride
- CBNumber:CB6146212
- Molecular Formula:C18H22ClNO
- Formula Weight:303.83
- MOL File:1798-50-1.mol
Diphenylpiperidin-4-ylmethanol hydrochloride Property
- Melting point 270-281 °C
- form Crystalline Powder
- color White to off-white
- CAS DataBase Reference 1798-50-1(CAS DataBase Reference)
- FDA UNII 4BXX0XNP9R
Safety
- Hazard Codes :Xi,T
- Risk Statements :36/37/38-25
- Safety Statements :24/25-45
- HazardClass :IRRITANT
- HS Code :29333999
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H319-H302
- Precautionary statements P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Diphenylpiperidin-4-ylmethanol hydrochloride Chemical Properties,Usage,Production
- Chemical Properties white to off-white crystalline powder
- Originator Frenquel,Merrell,US,1955
-
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C. - brand name Frenquel (Marion Merrell Dow).
- Therapeutic Function Tranquilizer
Diphenylpiperidin-4-ylmethanol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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- alpha,alpha-Diphenyl-4-piperidinomethanol hydrochloride,98%
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- alpha,alpha-diphenylpiperidine-4-methanol hydrochloride
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- gamma-pipradolhydrochloride
- frenquelhydrochloride
- alpha,alpha-diphenyl-4-piperidinemethanolhydrochloride
- alpha,alpha-diphenyl-4-piperidinemethanohydrochloride
- alpha-(4-piperidyl)benzhydrolhydrochloride
- ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL, HYDROCHLORIDE
- DIPHENYL-PIPERIDIN-4-YL-METHANOLHYDROCHLORIDE
- AZACYCLONOL HYDROCHLORIDE