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Clocapramine

Clocapramine Structure
Clocapramine
  • CAS No.47739-98-0
  • Chemical Name:Clocapramine
  • CBNumber:CB61178331
  • Molecular Formula:C28H37ClN4O
  • Formula Weight:481.07
  • MOL File:47739-98-0.mol
Clocapramine Property
  • Boiling point 662.1±55.0 °C(Predicted)
  • Density 1.23 g/cm3
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • pka 16.20±0.20(Predicted)
  • FDA UNII 6EEL1GB72K
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Clocapramine Chemical Properties,Usage,Production

  • Uses Clocapramine is an antagonist of the D2, 5-HT2A receptors.
  • Definition ChEBI: Clocapramine is a dibenzooxazepine.
  • in vivo

    Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].

  • IC 50 D2 Receptor; 5-HT2A Receptor
  • References [1] Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412. DOI:10.1254/jjp.69.399
    [2] Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. DOI:10.1038/sj.npp.1380239
Clocapramine Preparation Products And Raw materials
Raw materials
Preparation Products
Clocapramine Suppliers
Global(4)Suppliers
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Clocapramine Spectrum
47739-98-0, ClocapramineRelated Search:
  • C28H37ClN4O
  • 化合物 T10837L
  • 47739-98-0
  • [1,4'-Bipiperidine]-4'-carboxamide, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-
  • Clocarpramine
  • Clocapraminum [inn-latin]
  • Clocapraminum
  • Clocapramina [inn-spanish]
  • Clocapramina
  • 65016-29-7 (Di-hydrochloride monohydrate)
  • 28058-62-0 (Di-hydrochloride)
  • 1-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-4-piperidino-4-piperidinecarboxamide
  • 1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide
  • 3-chlorocarpipramine

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