Synthesis
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1H-indole-3-propylamine

Synthesis
1H-indole-3-propylamine Structure
1H-indole-3-propylamine
  • CAS No.6245-89-2
  • Chemical Name:1H-indole-3-propylamine
  • CBNumber:CB5927122
  • Molecular Formula:C11H14N2
  • Formula Weight:174.24
  • MOL File:6245-89-2.mol
1H-indole-3-propylamine Property
  • Melting point 64 °C
  • Boiling point 353.7±25.0 °C(Predicted)
  • Density 1.125±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
  • pka 17.29±0.30(Predicted)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319-H315-H335-H302
  • Precautionary statements P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

1H-indole-3-propylamine Chemical Properties,Usage,Production

  • Synthesis A solution of LAH (1.0 M in ether, 36.5 mL, 36.5 mmol) was cooled to 0 °C, and  a solution of the cyanoethyl indole (2.78 g, 16.3 mmol) was added slowly. Then, the solution was heated at reflflux for 3 h. It was cooled to 0 °C and quenched by dropwise addition of water (20 mL) followed by 1 N sodium hydroxide (40 mL). The phases were separated, and the aqueous phase was extracted with ether. The combined organic phases were washed with brine and then dried (potassium hydroxide). Evaporation of the solvent gave 2.6 g (92%) of homotryptamine as a yellow oil, which solidifified on standing. The hydrochloride was prepared by dissolving the amine in a minimum of ethanol and then a saturated solution of hydrogen chloride in ether was added until no additional salt formation was observed. The hydrochloride was recrystallized from ethanol.
    synthesis of 1H-indole-3-propylamine
    Reference: Kuehne, M. E.; Cowen, S. D.; Xu, F.; Borman, L. S. J. Org. Chem. 2001, 66, 5303–5316.
  • Chemical Properties Light yellow powder
1H-indole-3-propylamine Preparation Products And Raw materials
Raw materials
Preparation Products
1H-indole-3-propylamine Suppliers
Global(66)Suppliers
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1H-indole-3-propylamine Spectrum
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