Description
Salvianolic acid A is an antioxidant and free radical scavenging compound extracted from
S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties. It has been reported to reduce leukocyte-endothelial adherence, as well as inhibit inflammation and matrix metalloproteinases, suppress apoptosis, and reduce lipid peroxidation in damaged cardiac tissue.
Chemical Properties
Yellow Solid
Uses
ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated and the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL.
Definition
ChEBI: Salvianolic acid A is a stilbenoid.
General Description
Salvianolic acid A is a phenolic acid, isolated from Danshen, a traditional Chinese medicine, commonly used for the treatment of bone loss, chronic renal failure, hepatocirrhosis, hepatitis, coronary heart disease and cerebrovascular disease.
Biochem/physiol Actions
Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.
References
[1] JENNIFER HUI-CHUN HO Chuang Y H. Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.[J]. Journal of Biomedical Science, 2011: 30. DOI:
10.1186/1423-0127-18-30[2] GENG-TAO LIU. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes[J]. Biochemical pharmacology, 1992, 43 2: Pages 147-152. DOI:
10.1016/0006-2952(92)90271-j[3] HUAYING FAN. Cardioprotective effects of salvianolic Acid a on myocardial ischemia-reperfusion injury in vivo and in vitro.[J]. Evidence-based Complementary and Alternative Medicine, 2012: 508938. DOI:
10.1155/2012/508938
