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N-Ethylmaleimide

CAS No.128-53-0
Chemical Name:N-Ethylmaleimide
CBNumber:CB5748314
Molecular Formula:C6H7NO2
Formula Weight:125.13
MOL File:128-53-0.mol

N-Ethylmaleimide Property

Melting point 43-46 °C(lit.)
Boiling point 210 °C(lit.)
Density 1.2500 (rough estimate)
refractive index 1.4430 (estimate)
Flash point 73 °C
storage temp. 2-8°C
solubility methanol: 1 M at 20 °C, clear, colorless
form Crystalline Powder
pka -2.18±0.20(Predicted)
color White to off-white
biological source synthetic (organic)
Water Solubility 1 g/L (20 ºC)
Sensitive Light Sensitive
Merck 14,3822
BRN 112448
Stability Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
InChIKey HDFGOPSGAURCEO-UHFFFAOYSA-N
CAS DataBase Reference 128-53-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII O3C74ACM9V
NIST Chemistry Reference 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0)
EPA Substance Registry System N-Ethylmaleimide (128-53-0)
Absorption cut-off at 382nm in methanol at 1M
UNSPSC Code 12352209
NACRES NA.26

Safety

Hazard Codes :T+
Risk Statements :21-28-34-43-20/21
Safety Statements :26-28-36/37/39-45-28A
RIDADR :UN 2928 6.1/PG 2
WGK Germany :3
RTECS :UX9625000
F :19
TSCA :Yes
HazardClass :6.1
PackingGroup :II
HS Code :29251900

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H300-H311-H314-H317
Precautionary statements P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310

N-Ethylmaleimide Price More Price(28)

Brand: Sigma-Aldrich(India)
Product number: E3876
Product name : N-Ethylmaleimide
Purity: crystalline, ≥98% (HPLC)
Packaging: 5G
Price: ₹4427.43
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: E3876
Product name : N-Ethylmaleimide
Purity: crystalline, ≥98% (HPLC)
Packaging: 25G
Price: ₹14159.1
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: E3876
Product name : N-Ethylmaleimide
Purity: crystalline, ≥98% (HPLC)
Packaging: 100G
Price: ₹47478.45
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: E1271
Product name : N-Ethylmaleimide
Purity: BioXtra, ≥98% (HPLC)
Packaging: 1G
Price: ₹5109.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: E1271
Product name : N-Ethylmaleimide
Purity: BioXtra, ≥98% (HPLC)
Packaging: 5G
Price: ₹10143.03
Updated: 2022/06/14
Buy: Buy

N-Ethylmaleimide Chemical Properties,Usage,Production

Chemical Properties White solid
Uses In cancer research (possible antimitotic activity.)
Uses Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Uses N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.
Definition ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.
Hazard Lachrymator when liquid, a strong irritant.
Biochem/physiol Actions Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Safety Profile Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.