ChemicalBook > CAS DataBase List > 4-Chloro-2-methylphenol

4-Chloro-2-methylphenol

CAS No.1570-64-5
Chemical Name:4-Chloro-2-methylphenol
CBNumber:CB5690334
Molecular Formula:C7H7ClO
Formula Weight:142.58
MOL File:1570-64-5.mol

4-Chloro-2-methylphenol Property

Melting point 43-46 °C(lit.)
Boiling point 220-225 °C(lit.)
alpha 22 º (c=8,6N HCl)
Density 1.20
vapor pressure 26.66Pa at 19.85℃
refractive index 1.5449 (estimate)
Flash point >230 °F
storage temp. Inert atmosphere,Room Temperature
pka 9.87±0.18(Predicted)
form crystals
color white to brown
Water Solubility <0.1 g/100 mL at 15 ºC
BRN 1906684
InChIKey RHPUJHQBPORFGV-UHFFFAOYSA-N
LogP 3.09 at 20℃
CAS DataBase Reference 1570-64-5(CAS DataBase Reference)
EWG's Food Scores 2
FDA UNII 297V63W9RI
NIST Chemistry Reference Phenol, 4-chloro-2-methyl-(1570-64-5)
EPA Substance Registry System 4-Chloro-2-methylphenol (1570-64-5)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :T,C,N,Xn
Risk Statements :23-35-50-38-21/22
Safety Statements :26-36/37/39-45-61-28
RIDADR :UN 3437 6.1/PG 2
WGK Germany :2
RTECS :GO7120000
Hazard Note :Toxic/Corrosive
TSCA :Yes
HazardClass :6.1
PackingGroup :II
HS Code :29081990
Hazardous Substances Data :1570-64-5(Hazardous Substances Data)
Toxicity :mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03270,

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314-H331-H400
Precautionary statements P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

4-Chloro-2-methylphenol Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: C55208
Product name : 4-Chloro-2-methylphenol
Purity: 97%
Packaging: 10G
Price: ₹4784.65
Updated: 2022/06/14
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Brand: Sigma-Aldrich
Product number: 35833
Product name : 4-Chloro-2-methylphenol
Purity: PESTANAL?, analytical standard
Packaging: 100MG
Price: ₹11171.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 35833
Product name : 4-Chloro-2-methylphenol
Purity: PESTANAL?, analytical standard
Packaging: 100MG
Price: ₹11171.4
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: C0152
Product name : 4-Chloro-o-cresol
Purity: min. 90.0 %
Packaging: 25G
Price: ₹3800
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-L04164-14
Product name : 4-Chloro-2-methylphenol, 97%
Purity:
Packaging: 25g
Price: ₹12209
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4-Chloro-2-methylphenol Chemical Properties,Usage,Production

Chemical Properties Off-white to slightly brownish crystalline solid
Uses 4-Chloro-2-methylphenol is a transformation/degredation product of herbicides found in the environment through landfills and runoff.
Definition ChEBI: 4-chloro-2-methylphenol is a member of the class of phenols that is o-cresol in which the hydrogen para to the hydroxy group is replaced by a chlorine. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to an o-cresol.
Application 4-Chloro-2-methylphenol is an important pharmaceutical intermediate ingredient used in the manufacture of herbicides (Mecoprop, MCPA, and MCPB), as an additive tracer for resist plasma etching. It is used as a closed system intermediate in the production of phenoxy herbicides. It is also used as a disinfectant or bactericide.
Synthesis Reference(s) Tetrahedron Letters, 30, p. 5215, 1989 DOI: 10.1016/S0040-4039(01)93745-1
General Description Dark red flakes with waxy texture. Insoluble in water.
Air & Water Reactions Insoluble in water.
Reactivity Profile 4-Chloro-2-methylphenol can react vigorously with concentrated sodium hydroxide solutions. Also reacts with other bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys [NTP, 1992)]. A large quantity left in contact with concentrated sodium hydroxide solution for 3 days reacted violently, attaining red heat and evolving fumes that ignited explosively. The heat of reaction dissipated poorly because of the high viscosity of the mixture [Quart. Safety Summ., 1957, 28, 39].
Fire Hazard 4-Chloro-2-methylphenol is probably combustible.
Flammability and Explosibility Non flammable
Purification Methods Purify the phenol by crystallisation from pet ether (m 51o) and by zone melting. [Beilstein 6 H 359, 6 I 174, 6 II 332, 6 III 1264, 6 IV 1987.]