5-Chloro-2-nitrobenzotrifluoride

Description

5-Chloro-2-nitrobenzotrifluoride (5-chloro-2-nitrobenzotrifluoride) is an organic compound that is mainly used in the field of organic synthesis, especially in the pharmaceutical industry as an intermediate for the synthesis of certain drugs.

Chemical Properties

colorless to light yellow liquid

Uses

5-Chloro-2-nitrobenzotrifluoride serves as a reagent for synthesizing 2,6-dimethyl-4-(4-nitro-3-(trifluoromethyl)phenoxy)aniline by reacting with 4-amino-3,5-xylenol[1]. It reacts with hexadecylamine under reflux to produce N-hexadecyl-4-nitro-3-(trifluoromethyl)aniline (Amp-NTA)[2].

References

[1]Bong, S., Yeo, H., Ku, B.-C., Goh, M., & You, N.-H. (2017). Highly soluble polyimide based on asymmetric diamines containing trifluoromethyl group for high performance dielectric material. Macromolecular Research, 26(1), 85–91. https://doi.org/10.1007/s13233-018-6010-7
[2]Sharma, N., Dhyani, A. K., Marepally, S., & Jose, D. A. (2020). Nanoscale lipid vesicles functionalized with a nitro-aniline derivative for photoinduced nitric oxide (NO) delivery. Nanoscale Advances, 2(1), 463–469. https://doi.org/10.1039/c9na00532c