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Tetradecyltrimethylammonium bromide

Physical properties

CAS No.1119-97-7
Chemical Name:Tetradecyltrimethylammonium bromide
CBNumber:CB5335152
Molecular Formula:C17H38N.Br
Formula Weight:336.39
MOL File:1119-97-7.mol

Tetradecyltrimethylammonium bromide Property

Melting point 245-250 °C(lit.)
Density 1.1328 (rough estimate)
bulk density 600kg/m3
vapor pressure 0Pa at 25℃
refractive index 1.5260 (estimate)
storage temp. Store below +30°C.
solubility DMF: 2 mg/ml DMSO: 16 mg/ml Ethanol: 33 mg/ml PBS (pH 7.2): 5 mg/ml
form Fine Crystalline Powder
color White
PH pH (50g/l, 25℃ : 4.0～6.0
Water Solubility H2O:10%(w/v) 20 g/100 mL
Sensitive Hygroscopic
λmax λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02
Merck 14,6336
BRN 3633227
Stability Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKey CXRFDZFCGOPDTD-UHFFFAOYSA-M
LogP 2.2 at 20℃
CAS DataBase Reference 1119-97-7(CAS DataBase Reference)
EWG's Food Scores 4
FDA UNII 8483H94W1E
EPA Substance Registry System Tetradecyl trimethyl ammonium bromide (1119-97-7)
UNSPSC Code 41121801
NACRES NB.21

Safety

Hazard Codes :C
Risk Statements :34
Safety Statements :26-36/37/39-45-27
RIDADR :UN 3263 8/PG 2
WGK Germany :3
RTECS :BS5776000
F :3
TSCA :Yes
HazardClass :8
PackingGroup :II
HS Code :29239000
Toxicity :LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl)

NFPA 704:

	1
3		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H315-H318-H335-H373-H400
Precautionary statements P273-P280-P301+P312-P302+P352-P305+P351+P338-P314

Tetradecyltrimethylammonium bromide Price More Price(20)

Brand: Sigma-Aldrich(India)
Product number: T4762
Product name : Myristyltrimethylammonium bromide
Purity: ≥99%
Packaging: 5G
Price: ₹5466.63
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: T4762
Product name : Myristyltrimethylammonium bromide
Purity: ≥99%
Packaging: 100G
Price: ₹9850.75
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T4762
Product name : Myristyltrimethylammonium bromide
Purity: ≥99%
Packaging: 250G
Price: ₹9969.83
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T4762
Product name : Myristyltrimethylammonium bromide
Purity: ≥99%
Packaging: 500G
Price: ₹20848.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T4762
Product name : Myristyltrimethylammonium bromide
Purity: ≥99%
Packaging: 1KG
Price: ₹30050.2
Updated: 2022/06/14
Buy: Buy

Tetradecyltrimethylammonium bromide Chemical Properties,Usage,Production

Physical properties Cetrimide is a white fine powder crystal with a melting point of 245°C to 250°C. A rough estimate of its density is 1.1328. It is soluble in water with a solubility of 20 g/100 mL.
Description MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4
Uses Disinfectant; deodorant; laboratory reagent.
Uses Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis.
Definition Myristyltrimethylammonium bromide is an organic molecular entity.
General Description Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant.
Purification Methods Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]
References 1) ANNIE QUAN. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.[J]. Molecular Pharmacology, 2007, 72 6: 1425-1439. DOI:10.1124/mol.107.034207.
2) SAMIR VYAS. Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high-performance liquid chromatography.[J]. Journal of Pharmacy and Bioallied Sciences, 2011, 3 2: 310-314. DOI:10.4103/0975-7406.80766.
3) SIMON DE BECO. Endocytosis is required for E-cadherin redistribution at mature adherens junctions.[J]. ACS Catalysis , 2009: 7010-7015. DOI:10.1073/pnas.0811253106.
4) YOON HEE KIM . Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells[J]. Biochemical and biophysical research communications, 2016, 478 4: Pages 1609-1616. DOI:10.1016/j.bbrc.2016.08.165.