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17β-hydroxy Wortmannin

17β-hydroxy Wortmannin Structure
17β-hydroxy Wortmannin
  • CAS No.58053-83-1
  • Chemical Name:17β-hydroxy Wortmannin
  • CBNumber:CB53152437
  • Molecular Formula:C23H26O8
  • Formula Weight:430.45
  • MOL File:58053-83-1.mol
17β-hydroxy Wortmannin Property
  • Boiling point 615.4±55.0 °C(Predicted)
  • Density 1.39±0.1 g/cm3(Predicted)
  • storage temp. +2C to +8C
  • solubility DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml
  • form Off-white solid
  • pka 14.49±0.70(Predicted)
  • color off-white
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330
  • Precautionary statements P260-P262-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P320-P361+P364-P403+P233-P405-P501
17β-hydroxy Wortmannin Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 528119
  • Product name : PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
  • Purity: The PI 3-K Inhibitor XI, HWT, also referenced under CAS 58053-83-1, controls the biological activity of PI 3-K. This small molecule/inhibitor is prima
  • Packaging: 5MG
  • Price: ₹26250
  • Updated: 2022/06/14
  • Buy: Buy

17β-hydroxy Wortmannin Chemical Properties,Usage,Production

  • Description 17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.
  • Uses 17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].
  • in vivo

    17β-Hydroxywortmannin (0.1 μg/kg, p.o. for 5 weeks) exhibits activity in osteoclast differentation and prevent an estrogen-deficiency induced bone loss in ovafiectomized OVX rats[1].
    17β-Hydroxywortmannin (2.5 mg/kg/week, i.v. for 2 weeks) exhibits antitumor efficacy towards U87MG glioma with a therapeutic index of 26 in human tumor xenografted nude mice[2].

    Animal Model:ovafiectomized rat[1]
    Dosage:0.1 μg/kg/day
    Administration:p.o. for 5 weeks
    Result:Reduced the bone loss without significant toxicity.
    Animal Model:U87MG glioma xenografted nude mice[2]
    Dosage:2.5 mg/kg/week
    Administration:i.v. for 2 weeks
    Result:Inhibited tumor growth.
  • IC 50 PI3K: 0.5 nM (IC50)
  • References [1] Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56(4):336-8. DOI:10.1007/BF00318056
    [2] Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. DOI:10.1021/jm7012858
17β-hydroxy Wortmannin Preparation Products And Raw materials
Raw materials
Preparation Products
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17β-hydroxy Wortmannin Spectrum
  • 抑制剂
  • 17Β-羟基渥曼青霉素
  • 化合物 17Β-HYDROXYWORTMANNIN
  • 58053-83-1
  • PI 3-K Inhibitor XI, HWT
  • 17β-hydroxy Wortmannin
  • 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-
  • PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
  • 17.beta.-hydroxy Wortmannin
  • XLJORQYAOTYVQS-OGCOKEDGSA-N
  • 17β-hydroxy Wortmannin Exclusive

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