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GPRP (acetate)

GPRP (acetate) Structure
GPRP (acetate)
  • CAS No.157009-81-9
  • Chemical Name:GPRP (acetate)
  • CBNumber:CB53121103
  • Molecular Formula:C20H35N7O7
  • Formula Weight:485.54
  • MOL File:157009-81-9.mol
GPRP (acetate) Property
  • solubility PBS (pH 7.2): 10 mg/ml
  • form A crystalline solid
  • color White to off-white
  • Sequence H-Gly-Pro-Arg-Pro-OH
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

GPRP (acetate) Chemical Properties,Usage,Production

  • Uses GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3].
  • in vivo

    GPRP acetate (100 mg/kg; i.p., once daily for 10 days) significantly alleviates DSS-induced colitis through the improvement of body weight loss and mortality[3].

    Animal Model:C57BL/6 mice with dextran sulphate sodium (DSS)-induced colitis[3]
    Dosage:100 mg/kg
    Administration:Intraperitoneal injection; 100 mg/kg, once daily, for 10 days
    Result:Significantly inhibited body weight loss and reduced DSS-induced mortality and shortening of colon length, and decreased tissue damage and infiltration of inflammatory cells in colitis mice. Decreased levels of inflammatory cytokines in colitis mice.
  • References [1] Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. DOI:10.1016/0049-3848(95)e0088-8
    [2] Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. DOI:10.1021/jm00135a016
    [3] Zhang C, et al. Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. DOI:10.1016/j.jcmgh.2020.10.007
GPRP (acetate) Preparation Products And Raw materials
Raw materials
Preparation Products
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GPRP (acetate) Spectrum
157009-81-9, GPRP (acetate)Related Search:
  • 化学试剂
  • 抑制剂
  • 药靶配体
  • 目录肽
  • 目录多肽
  • 多肽
  • 醋酸GPRP
  • (S)-1-((S)-2-((S)-1-(2-氨基乙酰基)吡咯烷-2-甲酰胺基)-5-胍基戊酰基)吡咯烷-2-甲酸 复合物 乙酸 (1:1)
  • H-GLY-PRO-ARG-PRO-OH醋酸盐
  • GPRP (ACETATE);FIBRINOLYSIS INHIBITING FACTOR
  • 化合物GPRP ACETATE
  • 纤维蛋白原相关多肽
  • 甘氨酰- L- 脯氨酰- L- 精氨酰- L- 脯氨酸醋酸盐 (1:1)
  • 157009-81-9
  • (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid compound with acetic acid (1:1)
  • fibrinogen,GPRP acetate (67869 62 9 free base),Fibrin,inhibit,polymerization,GPRP,Pefa6003,IIb/IIIa,Pefa-6003,GPIIb/IIIa,glycoprotein,Inhibitor,platelet,GPRP acetate (67869629 free base)
  • L-Proline, glycyl-L-prolyl-L-arginyl-, acetate (1:1)
  • GPRP acetate (67869-62-9 free base)
  • GPRP acetate (Gly-Pro-Arg-Pro acetate
  • Pefabloc FG)
  • GPRP ACETATE, >98%
  • GPRP acetate,Gly-Pro-Arg-Pro acetate,Glycyl-L-prolyl-L-arginyl-L-proline acetate,Pefa 6003,Pefabloc FG, >98%
  • GLY-PRO-ARG-PRO ACETATE;PEFABLOC FG
  • Pefa 6003
  • H-Gly-Pro-Arg-Pro-OH (acetate)
  • GPRP (acetate)

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