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Aminoxy-PEG4-acid

Aminoxy-PEG4-acid Structure
Aminoxy-PEG4-acid
  • CAS No.1807537-38-7
  • Chemical Name:Aminoxy-PEG4-acid
  • CBNumber:CB53062330
  • Molecular Formula:C11H23NO7
  • Formula Weight:281.3
  • MOL File:1807537-38-7.mol
Aminoxy-PEG4-acid Property
  • Boiling point 448.6±45.0 °C(Predicted)
  • Density 1.170±0.06 g/cm3(Predicted)
  • solubility Soluble in Water, DMSO, DMF
  • pka 4.28±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Aminoxy-PEG4-acid Chemical Properties,Usage,Production

  • Description Aminooxy-PEG4-acid is a PEG linker containing an aminooxy group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. Aminooxy-PEG4-acid is not stable as a neat compound; it is sold as 1.0M aqueous solution.
  • Uses Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Aminoxy-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Aminoxy-PEG4-acid Suppliers
Global(35)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier：
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  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
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  • Supplier：
    Chongqing Chemdad Co., Ltd
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  • Supplier： Borenpharm Co., Ltd
  • Tel：027-65563561
  • Email：sales@borenpharm.com
  • Country：China
  • ProdList：1245
  • Advantage：55
Aminoxy-PEG4-acid Spectrum
1807537-38-7, Aminoxy-PEG4-acidRelated Search:
  • peg
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