Synthesis
4-(trifluoromethyl)-β-phenylalanine was used as the starting material, and the target compound BOC-(R)-3-amino-3-(4-fluorophenyl)-propionic acid was prepared by amino protection with di-tert-butyl dicarbonate [1]. The synthesis reaction formula of BOC-(R)-3-amino-3-(4-fluorophenyl)-propionic acid is shown in the figure below:
Uses
Boc-(R)-3-Amino-3-(4-fluoro-phenyl)propionic Acid is used as a reactant in the preparation of quinazoline compounds as modulators of complement alternative pathway for treating macular degeneration, diabetic retinopathy, and other diseases.
