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GW 627368X

GW 627368X Structure
GW 627368X
  • CAS No.439288-66-1
  • Chemical Name:GW 627368X
  • CBNumber:CB52591190
  • Molecular Formula:C30H28N2O6S
  • Formula Weight:544.62
  • MOL File:439288-66-1.mol
GW 627368X Property
  • Density 1.327±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
  • form Powder
  • pka 5.25±0.10(Predicted)
  • color White to off-white
  • FDA UNII A9P1ZGY0SE
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

GW 627368X Chemical Properties,Usage,Production

  • Description The effects of prostaglandin E2 (PGE2) are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 μM. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 μM.
  • Uses GW 627368 is a selective EP4 receptor competitive antagonist.
  • in vivo

    GW627368 (GW627368X) (0-15 mg/kg; p.o.; every alternate day for 28 days) shows significant tumor regression characterized by tumor reduction and induction of apoptosis[3].

    Animal Model:6-8 weeks Swiss albino mice[3]
    Dosage:0 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 15 mg/kg
    Administration:Oral administration, every alternate day for 28 days
    Result:Displayed anti-tumor and anti-proliferative potential in sarcoma 180 bearing mice.
  • IC 50 EP
GW 627368X Preparation Products And Raw materials
Raw materials
Preparation Products
GW 627368X Suppliers
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GW 627368X Spectrum
439288-66-1, GW 627368XRelated Search:
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 合成材料中间体
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 化合物GW 627368X,10 MM DMSO 溶液
  • GW 627368,EP4受体竞争性拮抗剂
  • 化合物GW 627368X
  • 2-(4-(4,9-二乙氧基-1-氧代-1H-苯并[F]异吲哚-2(3H)-基)苯基)-N-(苯基磺酰基)乙酰胺
  • 439288-66-1
  • GW627368, 10 mM in DMSO
  • N-(benzenesulfonyl)-2-(4-{4,9-diethoxy-1-oxo-1H,2H,3H-benzo[f]isoindol-2-yl}phenyl)acetamide
  • inhibit,Inhibitor,Prostaglandin Receptor,GW627368,GW 627368,GW-627368
  • Benzeneacetamide, 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-
  • 2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide
  • N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide
  • GW627368(GW627368X)
  • CS-1654
  • GW 627368;GW-627368;GW627368;GW-627368X;GW627368X;GW 627368X
  • 2-[4-(4,9-Diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-N-(phenylsulfonyl)acetamide
  • 4-(4,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide
  • GW 627368
  • GW 627368X

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