Description
Amodiaquine-d
10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of
P. falciparum in vitro (EC
50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of
P. berghei infection.
References
[1] S T MARIGA. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.[J]. Antimicrobial Agents and Chemotherapy, 2004, 48 11: 4089-4096. DOI:
10.1128/aac.48.11.4089-4096.2004[2] JULIANA M Sá T E W Jason L Chong. Malaria drug resistance: new observations and developments.[J]. Essays in biochemistry, 2011, 51: 137-160. DOI:
10.1042/bse0510137[3] R. JACOBS W C D Alling. AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE.[J]. Kisaengch’unghak chapchi. The Korean journal of parasitology, 1963, 11 1: 920-925. DOI:
10.2307/3275719
