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5-(trifluoromethyl)thiazol-2-amine

5-(trifluoromethyl)thiazol-2-amine Structure
5-(trifluoromethyl)thiazol-2-amine
  • CAS No.169260-97-3
  • Chemical Name:5-(trifluoromethyl)thiazol-2-amine
  • CBNumber:CB51559801
  • Molecular Formula:C4H3F3N2S
  • Formula Weight:168.14
  • MOL File:169260-97-3.mol
5-(trifluoromethyl)thiazol-2-amine Property
  • Boiling point 214.0±35.0 °C(Predicted)
  • Density 1.557±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
  • pka 2.61±0.10(Predicted)
Safety
  • RIDADR  :UN3077
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H302-H319-H410
  • Precautionary statements P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P273-P391-P501-P264-P270-P301+P312-P330-P501

5-(trifluoromethyl)thiazol-2-amine Chemical Properties,Usage,Production

  • Uses 5-(trifluoromethyl)thiazol-2-amine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
  • Synthesis Sodium dithionite (1.0 mmol) was added in one portion to a mixture of 2-aminothiazole (1.0 mmol), NaHCO3 (1.0 mmol) and polyfluoroalkyl iodide (1.5 mmol) in acetonitrile/water (4:1/v:v) at 5-10 °C under Ar atmosphere. The mixture was stirred until complete conversion of starting material as indicated by TLC analysis. Acetonitrile was removed under reduced pressure and water (5 mL) was added. The mixture was extracted with ethyl acetate (4.0 mL .x. 3) and the combined organic layers were dried over Na2SO4. The solvent was removed under vacuum and the residue was purified by column chromatography on silica gel (petroleum/ethyl acetate) to give the product.
5-(trifluoromethyl)thiazol-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
5-(trifluoromethyl)thiazol-2-amine Suppliers
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5-(trifluoromethyl)thiazol-2-amine Spectrum
  • 高端化学
  • 5-(三氟甲基)-1,3-噻唑-2-胺
  • 2-氨基-5-三氟甲基噻唑
  • 5-(三氟甲基)噻唑-2-胺
  • 169260-97-3
  • 2-Thiazolamine, 5-(trifluoromethyl)-
  • 5-(trifluoromethyl)-1,3-thiazol-2-amine
  • 2-Amino-5-trifluoromethyl-1,3-thiazole
  • 5-(trifluoromethyl)-2-Thiazolamine
  • 5-Trifluoromethyl-thiazol-2-ylamine
  • 2-aMino-5-trifluoroMethyl-thiazole
  • 5-(trifluoromethyl)thiazol-2-amine

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