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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Structure
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
  • CAS No.5428-80-8
  • Chemical Name:[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
  • CBNumber:CB51254607
  • Molecular Formula:C21H21ClN2O
  • Formula Weight:352.86
  • MOL File:5428-80-8.mol
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Property
  • Melting point 198-199.5 °C
  • Boiling point 551.4±50.0 °C(Predicted)
  • Density 1.244±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
  • form A crystalline solid
  • pka 13.22±0.20(Predicted)
  • color white to beige
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HS Code  :2933499090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H317-H319
  • Precautionary statements P280-P305+P351+P338

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Usage,Production

  • Description Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.
  • Uses Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Suppliers
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Spectrum
5428-80-8, [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanolRelated Search:
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  • [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

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