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A-METHYL-L-TRYPTOPHAN

CAS No.153-91-3
Chemical Name:A-METHYL-L-TRYPTOPHAN
CBNumber:CB5105786
Molecular Formula:C12H14N2O2
Formula Weight:218.26
MOL File:153-91-3.mol

A-METHYL-L-TRYPTOPHAN Property

Melting point 234 °C(Solv: ethanol, 60% (64-17-5))
Boiling point 444.0±35.0 °C(Predicted)
Density 1.314±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 2.34±0.10(Predicted)
form crystalline
color light yellow
FDA UNII 260VJL1C6Q
UNSPSC Code 12352209
NACRES NA.26

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

A-METHYL-L-TRYPTOPHAN Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: M8377
Product name : α-Methyl-DL-tryptophan
Purity: crystalline
Packaging: 100MG
Price: ₹3853.7
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M8377
Product name : α-Methyl-DL-tryptophan
Purity: crystalline
Packaging: 250MG
Price: ₹7794
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M8377
Product name : α-Methyl-DL-tryptophan
Purity: crystalline
Packaging: 1G
Price: ₹21152.05
Updated: 2022/06/14
Buy: Buy

A-METHYL-L-TRYPTOPHAN Chemical Properties,Usage,Production

Chemical Properties White to off-white powder
Uses α-methyl-DL-tryptophan is used as a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. It is also a substrate or non-transported inhibitor of the amino acid transporter PAT2 (slc36a2).
Biochem/physiol Actions α-methyl-DL-tryptophan is a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer.

in vivo

α-Methyl-DL-tryptophan (α-MT) (2 mg/mL; administered in drinking water; continuously administered; throughout the experimental period) inhibits tumor growth in BALB/c nude mice inoculated with ZR-75-1 cells^[1].
α-Methyl-DL-tryptophan (1 mg/mL; administered in drinking water; continuously administered; for 1 week) reduces body weight in wild-type mice on a high-fat diet^[2].

Animal Model:	BALB/c nude mice (female) inoculated with ZR-75-1 cells^[1]
Dosage:	2 mg/mL
Administration:	Administered in drinking water
Result:	Reduced the growth of ZR-75-1 cells. Tumor size was significantly smaller than that in the control group.

Animal Model:	Wild-type C57BL/6 male mice fed a high-fat diet^[2]
Dosage:	1 mg/mL
Administration:	Administered in drinking water, continuously for 1weeks
Result:	Led to a decrease in body weight.

A-METHYL-L-TRYPTOPHAN Preparation Products And Raw materials

Raw materials

Preparation Products

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