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GUVACINE HYDROCHLORIDE

GUVACINE HYDROCHLORIDE Structure
GUVACINE HYDROCHLORIDE
  • CAS No.6027-91-4
  • Chemical Name:GUVACINE HYDROCHLORIDE
  • CBNumber:CB4972615
  • Molecular Formula:C6H10ClNO2
  • Formula Weight:163.6021
  • MOL File:6027-91-4.mol
GUVACINE HYDROCHLORIDE Property
  • Melting point 316 °C (decomp)
  • storage temp. Inert atmosphere,Room Temperature
  • solubility H2O: soluble
  • form solid
  • color white
  • Water Solubility H2O: soluble
    ethanol: slightly soluble
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
  • HazardClass  :IRRITANT
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

GUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Chemical Properties Beige Solid
  • Uses Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
  • Uses Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.
  • Biological Activity Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
  • in vitro Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
GUVACINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
GUVACINE HYDROCHLORIDE Suppliers
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GUVACINE HYDROCHLORIDE Spectrum
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  • GUVACINE HYDROCHLORIDE
  • Guvacine hydrochloride >=97% (NMR), solid
  • 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
  • 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride
  • 1,2,5,6-Tetrahydro-
  • GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK

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