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Thiophene-2-ethylamine

CAS No.30433-91-1
Chemical Name:Thiophene-2-ethylamine
CBNumber:CB4853460
Molecular Formula:C6H9NS
Formula Weight:127.21
MOL File:30433-91-1.mol

Thiophene-2-ethylamine Property

Melting point 202 °C
Boiling point 200-201 °C/750 mmHg (lit.)
Density 1.087 g/mL at 25 °C (lit.)
refractive index n20/D 1.551(lit.)
Flash point 190 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka 9.47±0.10(Predicted)
form Liquid
Specific Gravity 1.087
color Colorless to yellow
Sensitive Air Sensitive
BRN 106962
InChIKey HVLUYXIJZLDNIS-UHFFFAOYSA-N
CAS DataBase Reference 30433-91-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xn,Xi
Risk Statements :20/21/22-36/37/38
Safety Statements :26-36-37/39
RIDADR :NA 1993 / PGIII
WGK Germany :3
HazardClass :IRRITANT
HazardClass :8
PackingGroup :II
HS Code :29339900

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H312+H332-H315-H319-H335
Precautionary statements P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

Thiophene-2-ethylamine Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: 423270
Product name : 2-Thiopheneethylamine
Purity: 96%
Packaging: 1G
Price: ₹2208.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 423270
Product name : 2-Thiopheneethylamine
Purity: 96%
Packaging: 5G
Price: ₹8421.85
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1637
Product name : 2-(2-Aminoethyl)thiophene
Purity: min. 98.0 %
Packaging: 5G
Price: ₹3600
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1637
Product name : 2-(2-Aminoethyl)thiophene
Purity: min. 98.0 %
Packaging: 25G
Price: ₹5800
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1637
Product name : 2-(2-Aminoethyl)thiophene
Purity: min. 98.0 %
Packaging: 250G
Price: ₹24500
Updated: 2022/05/26
Buy: Buy

Thiophene-2-ethylamine Chemical Properties,Usage,Production

Chemical Properties A colorless to yellow liquid with unstable properties requiring protection with nitrogen gas. It appears as a light yellow clear liquid, but turns red upon prolonged exposure.
Uses [2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90.
Uses 2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).
It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea.
General Description 2-Thiopheneethylamine (2-(thiophen-2-yl)ethanamine) is an aromatic amine. It undergoes microwave induced condensation with iminodiacetic acid to form the corresponding piperazine-2,6-dione derivatives. Its effect as a probable substitute to the pyridine ligand on the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells has been investigated.
Synthesis N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine.
References [1] M. BARWIOLEK. Structural and spectral studies of silver(I) complexes with new Schiff bases derived from 2-thiopheneethylamine and their application in thin layer deposition by spin and dip coating techniques[J]. Polyhedron, 2017, 124: Pages 12-21. DOI:10.1016/j.poly.2016.12.011.
[2] BHUSHAN D. VARPE S B J. Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity[J]. Russian Journal of Bioorganic Chemistry, 2022, 48 2: 372-379. DOI:10.1134/S1068162022020030.
[3] JUN YAN LEK. Understanding the Effect of Surface Chemistry on Charge Generation and Transport in Poly (3-hexylthiophene)/CdSe Hybrid Solar Cells[J]. ACS Applied Materials & Interfaces, 2011, 3 2: 287-292. DOI:10.1021/am100938f.
[4] SANDEEP KUMAR. Efficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives and their evaluation for anticancer activity[J]. Medicinal Chemistry Research, 2013, 22 10: 4600-4609. DOI:10.1007/s00044-012-0438-7.