Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Carotuximab Chemical Properties,Usage,Production
Uses
Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions[1][2].in vivo
Carotuximab (TRC105; 2 mg/kg; i.v; every 3 days; for 8 weeks) along with Decitabine results in a more durable anti-leukemic effect in acute myeloid leukemia (AML) xenografts. And also enhances reactive oxygen species (ROS) activity[2].
| Animal Model: | Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells[2] |
| Dosage: | 2 mg/kg |
| Administration: | i.v; every 3 days; for 8 weeks |
| Result: | Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts. |
References
[1] Katarina Tripska , et al. Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells. Front Med (Lausanne). 2022 Sep 7;9:845918. DOI:10.3389/fmed.2022.845918[2] June Baik, et al. Therapeutic effect of TRC105 and decitabine combination in AML xenografts. Heliyon. 2020 Oct 13;6(10):e05242. DOI:10.1016/j.heliyon.2020.e05242
Carotuximab Suppliers
Global(28)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354; | support@targetmol.com | 38999 | 58 | ||
| tp@aladdinsci.com | 54731 | 58 | |||
| 6206333 13167063860 | anhua.mao@aladdin-e.com | 49546 | 58 | ||
| 17316404525 17316404525 | 209533805@qq.com | 9790 | 58 | ||
| 15817493340 | 981810490@qq.com | 1577 | 58 | ||
| 027-65279366 18108604356 | products@biolabreagent.com | 9864 | 58 | ||
| 021-65675885 18964387627 | customer_service@efebio.com | 11963 | 58 | ||
| 0573-83568680 18057391398 | 3956524501@qq.com | 1441 | 58 | ||
| 027-65317797 15926423062 | 422450190@qq.com | 10300 | 58 | ||
| 177-54423994 17754423994 | 2853530910@QQ.com | 7999 | 62 |