Chemical Properties
White to slightly beige powder
Uses
Triphenylethylene is used in preparation of Esterase activated aggregation-induced luminescent anticancer prodrug.
Definition
ChEBI: Triphenylethylene is a stilbenoid. It is the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology.
Synthesis Reference(s)
Journal of the American Chemical Society, 78, p. 82, 1956
DOI: 10.1021/ja01582a025Organic Syntheses, Coll. Vol. 2, p. 606, 1943
Tetrahedron Letters, 14, p. 4193, 1973
Safety Profile
Experimental
reproductive effects. Questionable
carcinogen with experimental tumorigenic
data. Human mutation data reported. When
heated to decomposition it emits acrid
smoke and irritating fumes.
