Chemical Properties
White Powder
Uses
A metabolite of Midodrine. It induces alpha-adrenergic receptor stimulation of both arterial and venous systems without direct central nervous systme of cardiac effects. Midodrine Related Compound A
Definition
ChEBI: An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agon
st activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.
IC 50
α1A-adrenergic receptor: 5.89 (pKi); α1B-adrenergic receptor: 5.16 (pKi); rat alpha
1D-adrenergic receptor: 5.78 (pKi); human α2A-adrenoceptor: 5.83 (pKi)
