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L-Isoserine

L-Isoserine Structure
L-Isoserine
  • CAS No.632-13-3
  • Chemical Name:L-Isoserine
  • CBNumber:CB4394257
  • Molecular Formula:C3H7NO3
  • Formula Weight:105.09
  • MOL File:632-13-3.mol
L-Isoserine Property
  • Melting point 199~201℃
  • Boiling point 386.6±27.0 °C(Predicted)
  • Density 1.415±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • form powder to crystal
  • pka pK1:2.72(＋1);pK2:9.25(0) (25°C,μ=0.16)
  • color White to Almost white
  • Water Solubility Slightly soluble in water.
  • Sensitive Moisture Sensitive
  • InChI InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
  • InChIKey BMYNFMYTOJXKLE-REOHCLBHSA-N
  • SMILES C(O)(=O)[C@@H](O)CN
  • CAS DataBase Reference 632-13-3(CAS DataBase Reference)
  • UNSPSC Code 12352209
  • NACRES NA.22
Safety
  • WGK Germany  :3
  • F  :10-21
  • HS Code  :2922500090
  • NFPA 704:
    1
    0 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P280-P302+P352-P362+P364
L-Isoserine Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: 06054
  • Product name : L-Isoserine
  • Purity: ≥98.0% (TLC)
  • Packaging: 1G
  • Price: ₹12773.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0828
  • Product name : L-Isoserine
  • Purity: 
  • Packaging: 1G
  • Price: ₹6400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0828
  • Product name : L-Isoserine
  • Purity: 
  • Packaging: 5G
  • Price: ₹20800
  • Updated: 2022/05/26
  • Buy: Buy

L-Isoserine Chemical Properties,Usage,Production

  • Uses It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
  • reaction suitability reaction type: solution phase peptide synthesis
  • Biological Activity Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN.  L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].
  • References [1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
    [2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.
L-Isoserine Preparation Products And Raw materials
Raw materials
Preparation Products
L-Isoserine Suppliers
Global(219)Suppliers
  • Supplier：
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  • Advantage：60
  • Supplier：
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L-Isoserine Spectrum
632-13-3, L-IsoserineRelated Search:
  • (intermediate of isepamicin)
  • 化工中间体
  • 氨基酸
  • 医用原料
  • 杂质对照品
  • 抑制剂
  • 维生素及氨基酸
  • 合成材料中间体
  • 化学试剂
  • 助剂
  • 原料
  • 食品添加剂
  • 多肽
  • 生化试剂
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Serine Derivatives
  • Specialty Synthesis
  • 632-13-2
  • 632-11-1632-13-3
  • 288-16-5
  • 化合物 (S)-3-AMINO-2-HYDROXYPROPANOIC ACID
  • L-异丝氨酸,98%
  • (S)-2-羟基-3-氨基丙酸 10G
  • (S)-2-羟基-Β-丙氨酸
  • (S)-3-氨基-2-羟基丙酸
  • (S)-异丝氨酸
  • (S)-2-羟基-3-氨基丙酸
  • L-异丝氨酸
  • L-3-氨基-2-羟基丙酸
  • 632-13-3
  • <sc>L</sc>-Isoserine
  • Terbutaline Impurity 60
  • L-Isoserine USP/EP/BP
  • (2S)-3-amino-2-hydroxypropanoicaci
  • Propanoic acid, 3-amino-2-hydroxy-, (2S)-
  • L-Isoserine&gt
  • (S)-2-Hydroxy-β-alanine, (S)-3-Amino-2-hydroxypropionic acid
  • (S)-3-Amino-2-hydroxypropanoic acid
  • (-)-3-Amino-L-lactic acid
  • (2S)-3-AMINO-2-HYDROXY-PROPANOIC ACID
  • (S)-LSOSERINE
  • (s)-2-hydroxy-β-alanine
  • L-ISOSERINE
  • (S)-3-AMINO-2-HYDROXYPROPIONIC ACID
  • (S)-2-HYDROXY-BETA-ALANINE
  • (S)-2-HYDROXY-B-ALANINE
  • (S)-ISOSERINE

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