ChemicalBook > CAS DataBase List > m-PEG4-t-butyl ester
m-PEG4-t-butyl ester
- CAS No.883554-11-8
- Chemical Name:m-PEG4-t-butyl ester
- CBNumber:CB43062575
- Molecular Formula:C14H28O6
- Formula Weight:292.37
- MOL File:883554-11-8.mol
m-PEG4-t-butyl ester Property
- form Liquid
- color Colorless to off-white
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
m-PEG4-t-butyl ester Chemical Properties,Usage,Production
- Description m-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
- Uses m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
- IC 50 PEGs; Cleavable Linker
-
References
[1] Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.
[2] Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1.
m-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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883554-11-8, m-PEG4-t-butyl esterRelated Search:
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- 抑制剂
- 助剂
- 化合物 M-PEG4-BOC
- 2,5,8,11-四氧杂十四烷-14-酸叔丁酯
- 甲基-PEG3-丙酸叔丁酯
- 三甘醇单甲醚丙酸叔丁酯
- 883554-11-8
- tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate
- mPEG3-CH2CH2COOtBu
- 4,7,10,13-Tetraoxatetradecanoic acid, 1,1-dimethylethyl ester
- m-PEG4-Boc
- tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate/m-PEG4-t-butyl ester
- mPEG4-CH2CH2COOtBu
- m-PEG4-t-butyl ester
