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N,N'-Diisopropylcarbodiimide

CAS No.693-13-0
Chemical Name:N,N'-Diisopropylcarbodiimide
CBNumber:CB4301572
Molecular Formula:C7H14N2
Formula Weight:126.2
MOL File:693-13-0.mol

N,N'-Diisopropylcarbodiimide Property

Melting point 210-2120C (dec)
Boiling point 145-148 °C(lit.)
Density 0.815 g/mL at 20 °C(lit.)
vapor pressure 34.9hPa at 55.46℃
refractive index n20/D 1.433(lit.)
Flash point 93 °F
storage temp. Store below +30°C.
solubility Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form Liquid
color Clear colorless to yellow
Sensitive Moisture Sensitive
BRN 878281
Stability Volatile
InChIKey BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP 4.11 at 20℃
CAS DataBase Reference 693-13-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII OQO20I6TWH
NIST Chemistry Reference 2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System 2-Propanamine, N,N'-methanetetraylbis- (693-13-0)
UNSPSC Code 12352200
NACRES NA.22

Safety

Hazard Codes :T+,T,F,Xn
Risk Statements :10-26-36/37/38-41-42/43-37/38
Safety Statements :26-36/37/39-45-38-28A-16-22
RIDADR :UN 2929 6.1/PG 1
WGK Germany :3
RTECS :FF2175000
F :10-21
Hazard Note :Flammable/Highly Toxic/
TSCA :Yes
HazardClass :6.1
PackingGroup :II
HS Code :29252000
Hazardous Substances Data :693-13-0(Hazardous Substances Data)

NFPA 704:

	2
4		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H317-H318-H330-H334
Precautionary statements P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

N,N'-Diisopropylcarbodiimide Price More Price(19)

Brand: Sigma-Aldrich(India)
Product number: D125407
Product name : DIC
Purity: 99%
Packaging: 5G
Price: ₹885.49
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D125407
Product name : DIC
Purity: 99%
Packaging: 25G
Price: ₹3951.13
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D125407
Product name : DIC
Purity: 99%
Packaging: 100G
Price: ₹22018.05
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D125407
Product name : DIC
Purity: 99%
Packaging: 500G
Price: ₹60977.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 901609
Product name : Diisopropylcarbodiimide solution
Purity: 1?M in dichloromethane
Packaging: 25ML
Price: ₹11555.33
Updated: 2022/06/14
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N,N'-Diisopropylcarbodiimide Chemical Properties,Usage,Production

Description Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.
Chemical Properties N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.
Uses N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.
Definition ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.
General Description N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
reaction suitability reaction type: Coupling Reactions
Contact allergens It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.
Synthesis Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.