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VE 822

VE 822 Structure
VE 822
  • CAS No.1232416-25-9
  • Chemical Name:VE 822
  • CBNumber:CB42667115
  • Molecular Formula:C24H25N5O3S
  • Formula Weight:463.55
  • MOL File:1232416-25-9.mol
VE 822 Property
  • Melting point >197°C (dec.)
  • Boiling point 674.4±55.0 °C(Predicted)
  • Density 1.263±0.06 g/cm3(Predicted)
  • storage temp. Refrigerator
  • solubility DMSO (Slightly), Methanol (Slightly)
  • pka 8.88±0.10(Predicted)
  • form Solid
  • color Light Yellow
  • FDA UNII L423PRV3V3
  • NCI Drug Dictionary berzosertib
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338

VE 822 Chemical Properties,Usage,Production

  • Uses 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine is a novel ATR (ATM-Rad3-related) inhibitor for in vitro and in vivo radiosensatization.
  • Definition ChEBI: 3-[3-[4-(methylaminomethyl)phenyl]-5-isoxazolyl]-5-(4-propan-2-ylsulfonylphenyl)-2-pyrazinamine is a sulfonamide.
  • in vivo

    PSN-1 xenografts are treated with Berzosertib (VE-822) (60 mk/kg; d0, 1), NSC 613327 (100 mg/kg; d0) and/or XRT (6 Gy; d1). Tumors are then harvested 2 h post-XRT. Berzosertib (VE-822) inhibits p-Ser-345-Chk1 in xenografts after DNA-damaging agents, establishing VE-822 as a potent inhibitor of ATR in vivo. Besides, Berzosertib (VE-822) enhances the therapeutic efficacy of radiation (XRT) in MiaPaCa-2 and PSN-1 xenograft models[1].

  • IC 50 ATR: 0.2 nM (Ki); ATM: 34 nM (Ki); PI3Kγ: 220 nM (Ki)
VE 822 Preparation Products And Raw materials
Raw materials
Preparation Products
VE 822 Suppliers
Global(136)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    LEAP CHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：24727
  • Advantage：58
VE 822 Spectrum
1232416-25-9, VE 822Related Search:
  • Inhibitors
  • 有机原料类化合物
  • 药靶配体
  • 抑制剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 医药中间体
  • C24H25N5O3S
  • 5-[4-(异丙基磺酰基)苯基]-3-[3-[4-[(甲氨基)甲基]苯基]异噁唑-5-基]吡嗪-2-胺
  • M-6620;M-66207;VX-970;VE-822
  • 化合物BERZOSERTIB,10 MM DMSO 溶液
  • 贝索塞替尼
  • 2-氨基-3-[3-[4-[(甲氨基)甲基]苯基]-5-异噁唑基]-5-[4-(异丙基磺酰基)苯基]吡嗪
  • VE-822抑制剂
  • 5-(4-(异丙基磺酰)苯基)-3-(3-(4-((甲胺基)甲基)苯基)异恶唑-5-基)吡嗪-2-胺
  • M6620; M-6620; M 6620; VE822; VE-822; VE 822; VX970; VX-970; VX 970; BERZOSERTIB
  • 3-[3-[4-[(甲基氨基)甲基]苯基]-5-异恶唑基]-5-[4-[异丙磺酰基]苯基]-2-吡嗪胺(VE-822)
  • ATR抑制剂(VE-822)
  • 3-[3-[4-[(甲基氨基)甲基]苯基]-5-异恶唑基]-5-[4-[异丙磺酰基]苯基]-2-吡嗪胺
  • 1232416-25-9
  • M-66207
  • 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinam
  • Berzosertib, 10 mM in DMSO
  • 2-Amino-5-[4-(isopropylsulfonyl)phenyl]-3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]pyrazine
  • VE822 ATR inhibitor VE-822
  • 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
  • VX970 (VE-822)
  • VX970
  • M6620
  • Berzosertib
  • VE 822 USP/EP/BP
  • 3-(3-{4-[(methylamino)methyl]phenyl}-1,2-oxazol-5-yl)-5-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-amine
  • Berzosertib(VE-822)
  • VE-822 (Berzosertib)
  • 3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine
  • M6620; M-6620; M 6620; VE822; VE-822; VE 822; VX970; VX-970; VX 970;
  • M-6620
  • M 6620
  • Berzosertib (Synonyms: VE-822
  • VE-822 (VX-970)
  • CS-1487
  • VE822; VE 822
  • 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine
  • VE 822
  • VE 822 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine
  • 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE-822
  • 2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-

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