Description
Oleoyl serotonin-d17 contains 17 deuterium atoms at the 11, 11’, 12, 12’, 13, 13’, 14, 14’, 15, 15’, 16, 16’, 17, 17’, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleoyl serotonin by GC- or LC-mass spectrometry. Oleoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Item No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.1,2 Oleoyl Serotonin inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).1WARNING This product is not for human or veterinary use.
References
[1] GIORGIO ORTAR. New N-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain[J]. Journal of Medicinal Chemistry, 2007, 50 26: 6554-6569. DOI:
10.1021/jm070678q[2] S MAIONE. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors[J]. British Journal of Pharmacology, 2009, 150 6: 766-781. DOI:
10.1038/sj.bjp.0707145
